DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Heart rate. The EFO term heart rate was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: heart rate

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

M den Hoed, M Eijgelsheim, T Esko, BJ Brundel, DS Peal, DM Evans, IM Nolte, AV Segrè, H Holm, RE Handsaker, HJ Westra, T Johnson, A Isaacs, J Yang, A Lundby, JH Zhao, YJ Kim, MJ Go, P Almgren, M Bochud, G Boucher, MC Cornelis, D Gudbjartsson, D Hadley, P van der Harst, C Hayward, M den Heijer, W Igl, AU Jackson, Z Kutalik, J Luan, JP Kemp, K Kristiansson, C Ladenvall, M Lorentzon, ME Montasser, OT Njajou, PF O'Reilly, S Padmanabhan, B St Pourcain, T Rankinen, P Salo, T Tanaka, NJ Timpson, V Vitart, L Waite, W Wheeler, W Zhang, HH Draisma, MF Feitosa, KF Kerr, PA Lind, E Mihailov, NC Onland-Moret, C Song, MN Weedon, W Xie, L Yengo, D Absher, CM Albert, A Alonso, DE Arking, PI de Bakker, B Balkau, C Barlassina, P Benaglio, JC Bis, N Bouatia-Naji, S Brage, SJ Chanock, PS Chines, M Chung, D Darbar, C Dina, M Dörr, P Elliott, SB Felix, K Fischer, C Fuchsberger, EJ de Geus, P Goyette, V Gudnason, TB Harris, AL Hartikainen, AS Havulinna, SR Heckbert, AA Hicks, A Hofman, S Holewijn, F Hoogstra-Berends, JJ Hottenga, MK Jensen, A Johansson, J Junttila, S Kääb, B Kanon, S Ketkar, KT Khaw, JW Knowles, AS Kooner, JA Kors, M Kumari, L Milani, P Laiho, EG Lakatta, C Langenberg, M Leusink, Y Liu, RN Luben, KL Lunetta, SN Lynch, MR Markus, P Marques-Vidal, I Mateo Leach, WL McArdle, SA McCarroll, SE Medland, KA Miller, GW Montgomery, AC Morrison, M Müller-Nurasyid, P Navarro, M Nelis, JR O'Connell, CJ O'Donnell, KK Ong, AB Newman, A Peters, O Polasek, A Pouta, PP Pramstaller, BM Psaty, DC Rao, SM Ring, EJ Rossin, D Rudan, S Sanna, RA Scott, JS Sehmi, S Sharp, JT Shin, AB Singleton, AV Smith, N Soranzo, TD Spector, C Stewart, HM Stringham, KV Tarasov, AG Uitterlinden, L Vandenput, SJ Hwang, JB Whitfield, C Wijmenga, SH Wild, G Willemsen, JF Wilson, JC Witteman, A Wong, Q Wong, Y Jamshidi, P Zitting, JM Boer, DI Boomsma, IB Borecki, CM van Duijn, U Ekelund, NG Forouhi, P Froguel, A Hingorani, E Ingelsson, M Kivimaki, RA Kronmal, D Kuh, L Lind, NG Martin, BA Oostra, NL Pedersen, T Quertermous, JI Rotter, YT van der Schouw, WM Verschuren, M Walker, D Albanes, DO Arnar, TL Assimes, S Bandinelli, M Boehnke, RA de Boer, C Bouchard, WL Caulfield, JC Chambers, G Curhan, D Cusi, J Eriksson, L Ferrucci, WH van Gilst, N Glorioso, J de Graaf, L Groop, U Gyllensten, WC Hsueh, FB Hu, HV Huikuri, DJ Hunter, C Iribarren, B Isomaa, MR Jarvelin, A Jula, M Kähönen, LA Kiemeney, MM van der Klauw, JS Kooner, P Kraft, L Iacoviello, T Lehtimäki, ML Lokki, BD Mitchell, G Navis, MS Nieminen, C Ohlsson, NR Poulter, L Qi, OT Raitakari, EB Rimm, JD Rioux, F Rizzi, I Rudan, V Salomaa, PS Sever, DC Shields, AR Shuldiner, J Sinisalo, AV Stanton, RP Stolk, DP Strachan, JC Tardif, U Thorsteinsdottir, J Tuomilehto, DJ van Veldhuisen, J Virtamo, J Viikari, P Vollenweider, G Waeber, E Widen, YS Cho, JV Olsen, PM Visscher, C Willer, L Franke, J Erdmann, JR Thompson, A Pfeufer, N Sotoodehnia, C Newton-Cheh, PT Ellinor, BH Stricker, A Metspalu, M Perola, JS Beckmann, GD Smith, K Stefansson, NJ Wareham, PB Munroe, OC Sibon, DJ Milan, H Snieder, NJ Samani, RJ Loos

TITLE:

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.

JOURNAL:

Nature genetics Jun 2013, Vol 45, pp. 621-31

ABSTRACT:

Elevated resting heart rate is associated with greater risk of cardiovascular disease and mortality. In a 2-stage meta-analysis of genome-wide association studies in up to 181,171 individuals, we identified 14 new loci associated with heart rate and confirmed associations with all 7 previously established loci. Experimental downregulation of gene expression in Drosophila melanogaster and Danio rerio identified 20 genes at 11 loci that are relevant for heart rate regulation and highlight a role for genes involved in signal transmission, embryonic cardiac development and the pathophysiology of dilated cardiomyopathy, congenital heart failure and/or sudden cardiac death. In addition, genetic susceptibility to increased heart rate is associated with altered cardiac conduction and reduced risk of sick sinus syndrome, and both heart rate-increasing and heart rate-decreasing variants associate with risk of atrial fibrillation. Our findings provide fresh insights into the mechanisms regulating heart rate and identify new therapeutic targets. PUBMED: 23583979
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