DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Osteoprotegerin levels. The EFO term osteoprotegerin measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: osteoprotegerin measurement

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

JS Kwan, YH Hsu, CL Cheung, J Dupuis, A Saint-Pierre, J Eriksson, SK Handelman, A Aragaki, D Karasik, PP Pramstaller, C Kooperberg, AZ Lacroix, MG Larson, KS Lau, M Lorentzon, I Pichler, PC Sham, D Taliun, L Vandenput, DP Kiel, AA Hicks, RD Jackson, C Ohlsson, EJ Benjamin, AW Kung

TITLE:

Meta-analysis of genome-wide association studies identifies two loci associated with circulating osteoprotegerin levels.

JOURNAL:

Human molecular genetics Dec 2014, Vol 23, pp. 6684-93

ABSTRACT:

Osteoprotegerin (OPG) is involved in bone homeostasis and tumor cell survival. Circulating OPG levels are also important biomarkers of various clinical traits, such as cancers and atherosclerosis. OPG levels were measured in serum or in plasma. In a meta-analysis of genome-wide association studies in up to 10 336 individuals from European and Asian origin, we discovered that variants >100 kb upstream of the TNFRSF11B gene encoding OPG and another new locus on chromosome 17q11.2 were significantly associated with OPG variation. We also identified a suggestive locus on chromosome 14q21.2 associated with the trait. Moreover, we estimated that over half of the heritability of OPG levels could be explained by all variants examined in our study. Our findings provide further insight into the genetic regulation of circulating OPG levels. PUBMED: 25080503
Find other GeneSets from this publication