DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was C-reactive protein levels or LDL-cholesterol levels (pleiotropy). The EFO term low density lipoprotein cholesterol measurement, C-reactive protein measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: low density lipoprotein cholesterol measurement, C-reactive protein measurement

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

S Ligthart, A Vaez, YH Hsu, R Stolk, AG Uitterlinden, A Hofman, BZ Alizadeh, OH Franco, A Dehghan

TITLE:

Bivariate genome-wide association study identifies novel pleiotropic loci for lipids and inflammation.

JOURNAL:

BMC genomics Jun 2016, Vol 17, pp. 443

ABSTRACT:

Genome-wide association studies (GWAS) have identified multiple genetic loci for C-reactive protein (CRP) and lipids, of which some overlap. We aimed to identify genetic pleiotropy among CRP and lipids in order to better understand the shared biology of chronic inflammation and lipid metabolism. PUBMED: 27286809
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