DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Coronary heart disease. The EFO term coronary heart disease was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: coronary heart disease

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

X Lu, L Wang, S Chen, L He, X Yang, Y Shi, J Cheng, L Zhang, CC Gu, J Huang, T Wu, Y Ma, J Li, J Cao, J Chen, D Ge, Z Fan, Y Li, L Zhao, H Li, X Zhou, L Chen, D Liu, J Chen, X Duan, Y Hao, L Wang, F Lu, Z Liu, C Yao, C Shen, X Pu, L Yu, X Fang, L Xu, J Mu, X Wu, R Zheng, N Wu, Q Zhao, Y Li, X Liu, M Wang, D Yu, D Hu, X Ji, D Guo, D Sun, Q Wang, Y Yang, F Liu, Q Mao, X Liang, J Ji, P Chen, X Mo, D Li, G Chai, Y Tang, X Li, Z Du, X Liu, C Dou, Z Yang, Q Meng, D Wang, R Wang, J Yang, H Schunkert, NJ Samani, S Kathiresan, MP Reilly, J Erdmann, X Peng, X Wu, D Liu, Y Yang, R Chen, B Qiang, D Gu

TITLE:

Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease.

JOURNAL:

Nature genetics Jul 2012, Vol 44, pp. 890-4

ABSTRACT:

We performed a meta-analysis of 2 genome-wide association studies of coronary artery disease comprising 1,515 cases and 5,019 controls followed by replication studies in 15,460 cases and 11,472 controls, all of Chinese Han ancestry. We identify four new loci for coronary artery disease that reached the threshold of genome-wide significance (P < 5 × 10(-8)). These loci mapped in or near TTC32-WDR35, GUCY1A3, C6orf10-BTNL2 and ATP2B1. We also replicated four loci previously identified in European populations (in or near PHACTR1, TCF21, CDKN2A-CDKN2B and C12orf51). These findings provide new insights into pathways contributing to the susceptibility for coronary artery disease in the Chinese Han population. PUBMED: 22751097
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