DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Systemic lupus erythematosus. The EFO term systemic lupus erythematosus was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: systemic lupus erythematosus

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

JW Han, HF Zheng, Y Cui, LD Sun, DQ Ye, Z Hu, JH Xu, ZM Cai, W Huang, GP Zhao, HF Xie, H Fang, QJ Lu, JH Xu, XP Li, YF Pan, DQ Deng, FQ Zeng, ZZ Ye, XY Zhang, QW Wang, F Hao, L Ma, XB Zuo, FS Zhou, WH Du, YL Cheng, JQ Yang, SK Shen, J Li, YJ Sheng, XX Zuo, WF Zhu, F Gao, PL Zhang, Q Guo, B Li, M Gao, FL Xiao, C Quan, C Zhang, Z Zhang, KJ Zhu, Y Li, DY Hu, WS Lu, JL Huang, SX Liu, H Li, YQ Ren, ZX Wang, CJ Yang, PG Wang, WM Zhou, YM Lv, AP Zhang, SQ Zhang, D Lin, Y Li, HQ Low, M Shen, ZF Zhai, Y Wang, FY Zhang, S Yang, JJ Liu, XJ Zhang

TITLE:

Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.

JOURNAL:

Nature genetics Nov 2009, Vol 41, pp. 1234-7

ABSTRACT:

We performed a genome-wide association study (GWAS) of systemic lupus erythematosus (SLE) in a Chinese Han population by genotyping 1,047 cases and 1,205 controls using Illumina Human610-Quad BeadChips and replicating 78 SNPs in two additional cohorts (3,152 cases and 7,050 controls). We identified nine new susceptibility loci (ETS1, IKZF1, RASGRP3, SLC15A4, TNIP1, 7q11.23, 10q11.22, 11q23.3 and 16p11.2; 1.77 x 10(-25) < or = P(combined) < or = 2.77 x 10(-8)) and confirmed seven previously reported loci (BLK, IRF5, STAT4, TNFAIP3, TNFSF4, 6q21 and 22q11.21; 5.17 x 10(-42) < or = P(combined) < or = 5.18 x 10(-12)). Comparison with previous GWAS findings highlighted the genetic heterogeneity of SLE susceptibility between Chinese Han and European populations. This study not only advances our understanding of the genetic basis of SLE but also highlights the value of performing GWAS in diverse ancestral populations. PUBMED: 19838193
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