DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Fibrinogen. The EFO term fibrinogen measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: fibrinogen measurement

SCORE TYPE:

P-Value

THRESHOLD:

<= 0.05

GENES IN THRESHOLD:

41

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-10-22

SPECIES:

AUTHORS:

M Sabater-Lleal, J Huang, D Chasman, S Naitza, A Dehghan, AD Johnson, A Teumer, AP Reiner, L Folkersen, S Basu, AR Rudnicka, S Trompet, A Mälarstig, J Baumert, JC Bis, X Guo, JJ Hottenga, SY Shin, LM Lopez, J Lahti, T Tanaka, LR Yanek, T Oudot-Mellakh, JF Wilson, P Navarro, JE Huffman, T Zemunik, S Redline, R Mehra, D Pulanic, I Rudan, AF Wright, I Kolcic, O Polasek, SH Wild, H Campbell, JD Curb, R Wallace, S Liu, CB Eaton, DM Becker, LC Becker, S Bandinelli, K Räikkönen, E Widen, A Palotie, M Fornage, D Green, M Gross, G Davies, SE Harris, DC Liewald, JM Starr, FM Williams, PJ Grant, TD Spector, RJ Strawbridge, A Silveira, B Sennblad, F Rivadeneira, AG Uitterlinden, OH Franco, A Hofman, J van Dongen, G Willemsen, DI Boomsma, J Yao, N Swords Jenny, T Haritunians, B McKnight, T Lumley, KD Taylor, JI Rotter, BM Psaty, A Peters, C Gieger, T Illig, A Grotevendt, G Homuth, H Völzke, T Kocher, A Goel, MG Franzosi, U Seedorf, R Clarke, M Steri, KV Tarasov, S Sanna, D Schlessinger, DJ Stott, N Sattar, BM Buckley, A Rumley, GD Lowe, WL McArdle, MH Chen, GH Tofler, J Song, E Boerwinkle, AR Folsom, LM Rose, A Franco-Cereceda, M Teichert, MA Ikram, TH Mosley, S Bevan, M Dichgans, PM Rothwell, CL Sudlow, JC Hopewell, JC Chambers, D Saleheen, JS Kooner, J Danesh, CP Nelson, J Erdmann, MP Reilly, S Kathiresan, H Schunkert, PE Morange, L Ferrucci, JG Eriksson, D Jacobs, IJ Deary, N Soranzo, JC Witteman, EJ de Geus, RP Tracy, C Hayward, W Koenig, F Cucca, JW Jukema, P Eriksson, S Seshadri, HS Markus, H Watkins, NJ Samani, H Wallaschofski, NL Smith, D Tregouet, PM Ridker, W Tang, DP Strachan, A Hamsten, CJ O'Donnell

TITLE:

Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.

JOURNAL:

Circulation Sep 2013, Vol 128, pp. 1310-24

ABSTRACT:

Estimates of the heritability of plasma fibrinogen concentration, an established predictor of cardiovascular disease, range from 34% to 50%. Genetic variants so far identified by genome-wide association studies explain only a small proportion (<2%) of its variation. PUBMED: 23969696
Find other GeneSets from this publication