DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Weight. The EFO term body weight was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: body weight

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

G Thorleifsson, GB Walters, DF Gudbjartsson, V Steinthorsdottir, P Sulem, A Helgadottir, U Styrkarsdottir, S Gretarsdottir, S Thorlacius, I Jonsdottir, T Jonsdottir, EJ Olafsdottir, GH Olafsdottir, T Jonsson, F Jonsson, K Borch-Johnsen, T Hansen, G Andersen, T Jorgensen, T Lauritzen, KK Aben, AL Verbeek, N Roeleveld, E Kampman, LR Yanek, LC Becker, L Tryggvadottir, T Rafnar, DM Becker, J Gulcher, LA Kiemeney, O Pedersen, A Kong, U Thorsteinsdottir, K Stefansson

TITLE:

Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.

JOURNAL:

Nature genetics Jan 2009, Vol 41, pp. 18-24

ABSTRACT:

Obesity results from the interaction of genetic and environmental factors. To search for sequence variants that affect variation in two common measures of obesity, weight and body mass index (BMI), both of which are highly heritable, we performed a genome-wide association (GWA) study with 305,846 SNPs typed in 25,344 Icelandic, 2,998 Dutch, 1,890 European Americans and 1,160 African American subjects and combined the results with previously published results from the Diabetes Genetics Initiative (DGI) on 3,024 Scandinavians. We selected 43 variants in 19 regions for follow-up in 5,586 Danish individuals and compared the results to a genome-wide study on obesity-related traits from the GIANT consortium. In total, 29 variants, some correlated, in 11 chromosomal regions reached a genome-wide significance threshold of P < 1.6 x 10(-7). This includes previously identified variants close to or in the FTO, MC4R, BDNF and SH2B1 genes, in addition to variants at seven loci not previously connected with obesity. PUBMED: 19079260
Find other GeneSets from this publication