DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Bone mineral density (hip). The EFO term bone density was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: bone density

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

U Styrkarsdottir, BV Halldorsson, S Gretarsdottir, DF Gudbjartsson, GB Walters, T Ingvarsson, T Jonsdottir, J Saemundsdottir, S Snorradóttir, JR Center, TV Nguyen, P Alexandersen, JR Gulcher, JA Eisman, C Christiansen, G Sigurdsson, A Kong, U Thorsteinsdottir, K Stefansson

TITLE:

New sequence variants associated with bone mineral density.

JOURNAL:

Nature genetics Jan 2009, Vol 41, pp. 15-7

ABSTRACT:

In an extended genome-wide association study of bone mineral density among 6,865 Icelanders and a follow-up in 8,510 subjects of European descent, we identified four new genome-wide significant loci. These are near the SOST gene at 17q21, the MARK3 gene at 14q32, the SP7 gene at 12q13 and the TNFRSF11A (RANK) gene at 18q21. Furthermore, nonsynonymous SNPs in the C17orf53, LRP4, ADAM19 and IBSP genes were suggestively associated with bone density. PUBMED: 19079262
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