DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Spherical equivalent (joint main effects and education interaction). The EFO term self reported educational attainment, refractive error measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: self reported educational attainment, refractive error measurement

SCORE TYPE:

P-Value

THRESHOLD:

<= 0.05

GENES IN THRESHOLD:

31

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-10-22

SPECIES:

AUTHORS:

Q Fan, VJ Verhoeven, R Wojciechowski, VA Barathi, PG Hysi, JA Guggenheim, R Höhn, V Vitart, AP Khawaja, K Yamashiro, SM Hosseini, T Lehtimäki, Y Lu, T Haller, J Xie, C Delcourt, M Pirastu, J Wedenoja, P Gharahkhani, C Venturini, M Miyake, AW Hewitt, X Guo, J Mazur, JE Huffman, KM Williams, O Polasek, H Campbell, I Rudan, Z Vatavuk, JF Wilson, PK Joshi, G McMahon, B St Pourcain, DM Evans, CL Simpson, TH Schwantes-An, RP Igo, A Mirshahi, A Cougnard-Gregoire, C Bellenguez, M Blettner, O Raitakari, M Kähönen, I Seppala, T Zeller, T Meitinger, JS Ried, C Gieger, L Portas, EM van Leeuwen, N Amin, AG Uitterlinden, F Rivadeneira, A Hofman, JR Vingerling, YX Wang, X Wang, E Tai-Hui Boh, MK Ikram, C Sabanayagam, P Gupta, V Tan, L Zhou, CE Ho, W Lim, RW Beuerman, R Siantar, ES Tai, E Vithana, E Mihailov, CC Khor, C Hayward, RN Luben, PJ Foster, BE Klein, R Klein, HS Wong, P Mitchell, A Metspalu, T Aung, TL Young, M He, O Pärssinen, CM van Duijn, J Jin Wang, C Williams, JB Jonas, YY Teo, DA Mackey, K Oexle, N Yoshimura, AD Paterson, N Pfeiffer, TY Wong, PN Baird, D Stambolian, JE Wilson, CY Cheng, CJ Hammond, CC Klaver, SM Saw, JS Rahi, JF Korobelnik, JP Kemp, NJ Timpson, GD Smith, JE Craig, KP Burdon, RD Fogarty, SK Iyengar, E Chew, S Janmahasatian, NG Martin, S MacGregor, L Xu, M Schache, V Nangia, S Panda-Jonas, AF Wright, JR Fondran, JH Lass, S Feng, JH Zhao, KT Khaw, NJ Wareham, T Rantanen, J Kaprio, CP Pang, LJ Chen, PO Tam, V Jhanji, AL Young, A Döring, LJ Raffel, MF Cotch, X Li, SP Yip, MK Yap, G Biino, S Vaccargiu, M Fossarello, B Fleck, S Yazar, JW Tideman, M Tedja, MM Deangelis, M Morrison, L Farrer, X Zhou, W Chen, N Mizuki, A Meguro, KM Mäkelä

TITLE:

Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error.

JOURNAL:

Nature communications Mar 2016, Vol 7, pp. 11008

ABSTRACT:

Myopia is the most common human eye disorder and it results from complex genetic and environmental causes. The rapidly increasing prevalence of myopia poses a major public health challenge. Here, the CREAM consortium performs a joint meta-analysis to test single-nucleotide polymorphism (SNP) main effects and SNP × education interaction effects on refractive error in 40,036 adults from 25 studies of European ancestry and 10,315 adults from 9 studies of Asian ancestry. In European ancestry individuals, we identify six novel loci (FAM150B-ACP1, LINC00340, FBN1, DIS3L-MAP2K1, ARID2-SNAT1 and SLC14A2) associated with refractive error. In Asian populations, three genome-wide significant loci AREG, GABRR1 and PDE10A also exhibit strong interactions with education (P<8.5 × 10(-5)), whereas the interactions are less evident in Europeans. The discovery of these loci represents an important advance in understanding how gene and environment interactions contribute to the heterogeneity of myopia. PUBMED: 27020472
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