DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Caffeine consumption. The EFO term coffee consumption was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: coffee consumption

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

MC Cornelis, KL Monda, K Yu, N Paynter, EM Azzato, SN Bennett, SI Berndt, E Boerwinkle, S Chanock, N Chatterjee, D Couper, G Curhan, G Heiss, FB Hu, DJ Hunter, K Jacobs, MK Jensen, P Kraft, MT Landi, JA Nettleton, MP Purdue, P Rajaraman, EB Rimm, LM Rose, N Rothman, D Silverman, R Stolzenberg-Solomon, A Subar, M Yeager, DI Chasman, RM van Dam, NE Caporaso

TITLE:

Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption.

JOURNAL:

PLoS genetics Apr 2011, Vol 7, pp. e1002033

ABSTRACT:

We report the first genome-wide association study of habitual caffeine intake. We included 47,341 individuals of European descent based on five population-based studies within the United States. In a meta-analysis adjusted for age, sex, smoking, and eigenvectors of population variation, two loci achieved genome-wide significance: 7p21 (P = 2.4 × 10(-19)), near AHR, and 15q24 (P = 5.2 × 10(-14)), between CYP1A1 and CYP1A2. Both the AHR and CYP1A2 genes are biologically plausible candidates as CYP1A2 metabolizes caffeine and AHR regulates CYP1A2. PUBMED: 21490707
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