DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Obesity. The EFO term obesity was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: obesity

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

JP Bradfield, HR Taal, NJ Timpson, A Scherag, C Lecoeur, NM Warrington, E Hypponen, C Holst, B Valcarcel, E Thiering, RM Salem, FR Schumacher, DL Cousminer, PM Sleiman, J Zhao, RI Berkowitz, KS Vimaleswaran, I Jarick, CE Pennell, DM Evans, B St Pourcain, DJ Berry, DO Mook-Kanamori, A Hofman, F Rivadeneira, AG Uitterlinden, CM van Duijn, RJ van der Valk, JC de Jongste, DS Postma, DI Boomsma, WJ Gauderman, MT Hassanein, CM Lindgren, R Mägi, CA Boreham, CE Neville, LA Moreno, P Elliott, A Pouta, AL Hartikainen, M Li, O Raitakari, T Lehtimäki, JG Eriksson, A Palotie, J Dallongeville, S Das, P Deloukas, G McMahon, SM Ring, JP Kemp, JL Buxton, AI Blakemore, M Bustamante, M Guxens, JN Hirschhorn, MW Gillman, E Kreiner-Møller, H Bisgaard, FD Gilliland, J Heinrich, E Wheeler, I Barroso, S O'Rahilly, A Meirhaeghe, TI Sørensen, C Power, LJ Palmer, A Hinney, E Widen, IS Farooqi, MI McCarthy, P Froguel, D Meyre, J Hebebrand, MR Jarvelin, VW Jaddoe, GD Smith, H Hakonarson, SF Grant

TITLE:

A genome-wide association meta-analysis identifies new childhood obesity loci.

JOURNAL:

Nature genetics May 2012, Vol 44, pp. 526-31

ABSTRACT:

Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made in establishing genetic influences on common early-onset obesity. We performed a North American, Australian and European collaborative meta-analysis of 14 studies consisting of 5,530 cases (≥95th percentile of body mass index (BMI)) and 8,318 controls (<50th percentile of BMI) of European ancestry. Taking forward the eight newly discovered signals yielding association with P < 5 × 10(-6) in nine independent data sets (2,818 cases and 4,083 controls), we observed two loci that yielded genome-wide significant combined P values near OLFM4 at 13q14 (rs9568856; P = 1.82 × 10(-9); odds ratio (OR) = 1.22) and within HOXB5 at 17q21 (rs9299; P = 3.54 × 10(-9); OR = 1.14). Both loci continued to show association when two extreme childhood obesity cohorts were included (2,214 cases and 2,674 controls). These two loci also yielded directionally consistent associations in a previous meta-analysis of adult BMI(1). PUBMED: 22484627
Find other GeneSets from this publication