DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Prostate cancer. The EFO term prostate carcinoma was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: prostate carcinoma

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

J Gudmundsson, P Sulem, DF Gudbjartsson, G Masson, BA Agnarsson, KR Benediktsdottir, A Sigurdsson, OT Magnusson, SA Gudjonsson, DN Magnusdottir, H Johannsdottir, HT Helgadottir, SN Stacey, A Jonasdottir, SB Olafsdottir, G Thorleifsson, JG Jonasson, L Tryggvadottir, S Navarrete, F Fuertes, BT Helfand, Q Hu, IE Csiki, IN Mates, V Jinga, KK Aben, IM van Oort, SH Vermeulen, JL Donovan, FC Hamdy, CF Ng, PK Chiu, KM Lau, MC Ng, JR Gulcher, A Kong, WJ Catalona, JI Mayordomo, GV Einarsson, RB Barkardottir, E Jonsson, D Mates, DE Neal, LA Kiemeney, U Thorsteinsdottir, T Rafnar, K Stefansson

TITLE:

A study based on whole-genome sequencing yields a rare variant at 8q24 associated with prostate cancer.

JOURNAL:

Nature genetics Dec 2012, Vol 44, pp. 1326-9

ABSTRACT:

In Western countries, prostate cancer is the most prevalent cancer of men and one of the leading causes of cancer-related death in men. Several genome-wide association studies have yielded numerous common variants conferring risk of prostate cancer. Here, we analyzed 32.5 million variants discovered by whole-genome sequencing 1,795 Icelanders. We identified a new low-frequency variant at 8q24 associated with prostate cancer in European populations, rs188140481[A] (odds ratio (OR) = 2.90; P(combined) = 6.2 × 10(-34)), with an average risk allele frequency in controls of 0.54%. This variant is only very weakly correlated (r(2) ≤ 0.06) with previously reported risk variants at 8q24, and its association remains significant after adjustment for all known risk-associated variants. Carriers of rs188140481[A] were diagnosed with prostate cancer 1.26 years younger than non-carriers (P = 0.0059). We also report results for a previously described HOXB13 variant (rs138213197[T]), confirming it as a prostate cancer risk variant in populations from across Europe. PUBMED: 23104005
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