DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Schizophrenia. The EFO term schizophrenia was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: schizophrenia

SCORE TYPE:

P-Value

THRESHOLD:

<= 0.05

GENES IN THRESHOLD:

117

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-10-22

SPECIES:

AUTHORS:

S Ripke, C O'Dushlaine, K Chambert, JL Moran, AK Kähler, S Akterin, SE Bergen, AL Collins, JJ Crowley, M Fromer, Y Kim, SH Lee, PK Magnusson, N Sanchez, EA Stahl, S Williams, NR Wray, K Xia, F Bettella, AD Borglum, BK Bulik-Sullivan, P Cormican, N Craddock, C de Leeuw, N Durmishi, M Gill, V Golimbet, ML Hamshere, P Holmans, DM Hougaard, KS Kendler, K Lin, DW Morris, O Mors, PB Mortensen, BM Neale, FA O'Neill, MJ Owen, MP Milovancevic, D Posthuma, J Powell, AL Richards, BP Riley, D Ruderfer, D Rujescu, E Sigurdsson, T Silagadze, AB Smit, H Stefansson, S Steinberg, J Suvisaari, S Tosato, M Verhage, JT Walters, DF Levinson, PV Gejman, KS Kendler, C Laurent, BJ Mowry, MC O'Donovan, MJ Owen, AE Pulver, BP Riley, SG Schwab, DB Wildenauer, F Dudbridge, P Holmans, J Shi, M Albus, M Alexander, D Campion, D Cohen, D Dikeos, J Duan, P Eichhammer, S Godard, M Hansen, FB Lerer, KY Liang, W Maier, J Mallet, DA Nertney, G Nestadt, N Norton, FA O'Neill, GN Papadimitriou, R Ribble, AR Sanders, JM Silverman, D Walsh, NM Williams, B Wormley, MJ Arranz, S Bakker, S Bender, E Bramon, D Collier, B Crespo-Facorro, J Hall, C Iyegbe, A Jablensky, RS Kahn, L Kalaydjieva, S Lawrie, CM Lewis, K Lin, DH Linszen, I Mata, A McIntosh, RM Murray, RA Ophoff, J Powell, D Rujescu, J Van Os, M Walshe, M Weisbrod, D Wiersma, P Donnelly, I Barroso, JM Blackwell, E Bramon, MA Brown, JP Casas, AP Corvin, P Deloukas, A Duncanson, J Jankowski, HS Markus, CG Mathew, CN Palmer, R Plomin, A Rautanen, SJ Sawcer, RC Trembath, AC Viswanathan, NW Wood, CC Spencer, G Band, C Bellenguez, C Freeman, G Hellenthal, E Giannoulatou, M Pirinen, RD Pearson, A Strange, Z Su, D Vukcevic, P Donnelly, C Langford, SE Hunt, S Edkins, R Gwilliam, H Blackburn, SJ Bumpstead, S Dronov, M Gillman, E Gray, N Hammond, A Jayakumar, OT McCann, J Liddle, SC Potter, R Ravindrarajah, M Ricketts, A Tashakkori-Ghanbaria, MJ Waller, P Weston, S Widaa, P Whittaker, I Barroso, P Deloukas, CG Mathew, JM Blackwell, MA Brown, AP Corvin, MI McCarthy, CC Spencer, E Bramon, AP Corvin, MC O'Donovan, K Stefansson, E Scolnick, S Purcell, SA McCarroll, P Sklar, CM Hultman, PF Sullivan

TITLE:

Genome-wide association analysis identifies 13 new risk loci for schizophrenia.

JOURNAL:

Nature genetics Oct 2013, Vol 45, pp. 1150-9

ABSTRACT:

Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial public health impact. We conducted a multi-stage genome-wide association study (GWAS) for schizophrenia beginning with a Swedish national sample (5,001 cases and 6,243 controls) followed by meta-analysis with previous schizophrenia GWAS (8,832 cases and 12,067 controls) and finally by replication of SNPs in 168 genomic regions in independent samples (7,413 cases, 19,762 controls and 581 parent-offspring trios). We identified 22 loci associated at genome-wide significance; 13 of these are new, and 1 was previously implicated in bipolar disorder. Examination of candidate genes at these loci suggests the involvement of neuronal calcium signaling. We estimate that 8,300 independent, mostly common SNPs (95% credible interval of 6,300-10,200 SNPs) contribute to risk for schizophrenia and that these collectively account for at least 32% of the variance in liability. Common genetic variation has an important role in the etiology of schizophrenia, and larger studies will allow more detailed understanding of this disorder. PUBMED: 23974872
Find other GeneSets from this publication