DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Survival in sporadic amyotrophic lateral sclerosis. The EFO term sporadic amyotrophic lateral sclerosis, survival time was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: sporadic amyotrophic lateral sclerosis, survival time

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

I Fogh, K Lin, C Tiloca, J Rooney, C Gellera, FP Diekstra, A Ratti, A Shatunov, MA van Es, P Proitsi, A Jones, W Sproviero, A Chiò, RL McLaughlin, G Sorarù, L Corrado, D Stahl, R Del Bo, C Cereda, B Castellotti, JD Glass, S Newhouse, R Dobson, BN Smith, S Topp, W van Rheenen, V Meininger, J Melki, KE Morrison, PJ Shaw, PN Leigh, PM Andersen, GP Comi, N Ticozzi, L Mazzini, S D'Alfonso, BJ Traynor, P Van Damme, W Robberecht, RH Brown, JE Landers, O Hardiman, CM Lewis, LH van den Berg, CE Shaw, JH Veldink, V Silani, A Al-Chalabi, J Powell

TITLE:

Association of a Locus in the CAMTA1 Gene With Survival in Patients With Sporadic Amyotrophic Lateral Sclerosis.

JOURNAL:

JAMA neurology Jul 2016, Vol 73, pp. 812-20

ABSTRACT:

Amyotrophic lateral sclerosis (ALS) is a devastating adult-onset neurodegenerative disorder with a poor prognosis and a median survival of 3 years. However, a significant proportion of patients survive more than 10 years from symptom onset. PUBMED: 27244217
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