DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Bipolar disorder. The EFO term bipolar disorder was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: bipolar disorder

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

TW Mühleisen, M Leber, TG Schulze, J Strohmaier, F Degenhardt, J Treutlein, M Mattheisen, AJ Forstner, J Schumacher, R Breuer, S Meier, S Herms, P Hoffmann, A Lacour, SH Witt, A Reif, B Müller-Myhsok, S Lucae, W Maier, M Schwarz, H Vedder, J Kammerer-Ciernioch, A Pfennig, M Bauer, M Hautzinger, S Moebus, L Priebe, PM Czerski, J Hauser, J Lissowska, N Szeszenia-Dabrowska, P Brennan, JD McKay, A Wright, PB Mitchell, JM Fullerton, PR Schofield, GW Montgomery, SE Medland, SD Gordon, NG Martin, V Krasnow, A Chuchalin, G Babadjanova, G Pantelejeva, LI Abramova, AS Tiganov, A Polonikov, E Khusnutdinova, M Alda, P Grof, GA Rouleau, G Turecki, C Laprise, F Rivas, F Mayoral, M Kogevinas, M Grigoroiu-Serbanescu, P Propping, T Becker, M Rietschel, MM Nöthen, S Cichon

TITLE:

Genome-wide association study reveals two new risk loci for bipolar disorder.

JOURNAL:

Nature communications Mar 2014, Vol 5, pp. 3339

ABSTRACT:

Bipolar disorder (BD) is a common and highly heritable mental illness and genome-wide association studies (GWAS) have robustly identified the first common genetic variants involved in disease aetiology. The data also provide strong evidence for the presence of multiple additional risk loci, each contributing a relatively small effect to BD susceptibility. Large samples are necessary to detect these risk loci. Here we present results from the largest BD GWAS to date by investigating 2.3 million single-nucleotide polymorphisms (SNPs) in a sample of 24,025 patients and controls. We detect 56 genome-wide significant SNPs in five chromosomal regions including previously reported risk loci ANK3, ODZ4 and TRANK1, as well as the risk locus ADCY2 (5p15.31) and a region between MIR2113 and POU3F2 (6q16.1). ADCY2 is a key enzyme in cAMP signalling and our finding provides new insights into the biological mechanisms involved in the development of BD. PUBMED: 24618891
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