DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Gout. The EFO term gout was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: gout

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

C Li, Z Li, S Liu, C Wang, L Han, L Cui, J Zhou, H Zou, Z Liu, J Chen, X Cheng, Z Zhou, C Ding, M Wang, T Chen, Y Cui, H He, K Zhang, C Yin, Y Wang, S Xing, B Li, J Ji, Z Jia, L Ma, J Niu, Y Xin, T Liu, N Chu, Q Yu, W Ren, X Wang, A Zhang, Y Sun, H Wang, J Lu, Y Li, Y Qing, G Chen, Y Wang, L Zhou, H Niu, J Liang, Q Dong, X Li, QS Mi, Y Shi

TITLE:

Genome-wide association analysis identifies three new risk loci for gout arthritis in Han Chinese.

JOURNAL:

Nature communications May 2015, Vol 6, pp. 7041

ABSTRACT:

Gout is one of the most common types of inflammatory arthritis, caused by the deposition of monosodium urate crystals in and around the joints. Previous genome-wide association studies (GWASs) have identified many genetic loci associated with raised serum urate concentrations. However, hyperuricemia alone is not sufficient for the development of gout arthritis. Here we conduct a multistage GWAS in Han Chinese using 4,275 male gout patients and 6,272 normal male controls (1,255 cases and 1,848 controls were genome-wide genotyped), with an additional 1,644 hyperuricemic controls. We discover three new risk loci, 17q23.2 (rs11653176, P=1.36 × 10(-13), BCAS3), 9p24.2 (rs12236871, P=1.48 × 10(-10), RFX3) and 11p15.5 (rs179785, P=1.28 × 10(-8), KCNQ1), which contain inflammatory candidate genes. Our results suggest that these loci are most likely related to the progression from hyperuricemia to inflammatory gout, which will provide new insights into the pathogenesis of gout arthritis. PUBMED: 25967671
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