DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Type 2 diabetes. The EFO term type II diabetes mellitus was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: type II diabetes mellitus

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

BF Voight, LJ Scott, V Steinthorsdottir, AP Morris, C Dina, RP Welch, E Zeggini, C Huth, YS Aulchenko, G Thorleifsson, LJ McCulloch, T Ferreira, H Grallert, N Amin, G Wu, CJ Willer, S Raychaudhuri, SA McCarroll, C Langenberg, OM Hofmann, J Dupuis, L Qi, AV Segrè, M van Hoek, P Navarro, K Ardlie, B Balkau, R Benediktsson, AJ Bennett, R Blagieva, E Boerwinkle, LL Bonnycastle, K Bengtsson Boström, B Bravenboer, S Bumpstead, NP Burtt, G Charpentier, PS Chines, M Cornelis, DJ Couper, G Crawford, AS Doney, KS Elliott, AL Elliott, MR Erdos, CS Fox, CS Franklin, M Ganser, C Gieger, N Grarup, T Green, S Griffin, CJ Groves, C Guiducci, S Hadjadj, N Hassanali, C Herder, B Isomaa, AU Jackson, PR Johnson, T Jørgensen, WH Kao, N Klopp, A Kong, P Kraft, J Kuusisto, T Lauritzen, M Li, A Lieverse, CM Lindgren, V Lyssenko, M Marre, T Meitinger, K Midthjell, MA Morken, N Narisu, P Nilsson, KR Owen, F Payne, JR Perry, AK Petersen, C Platou, C Proença, I Prokopenko, W Rathmann, NW Rayner, NR Robertson, G Rocheleau, M Roden, MJ Sampson, R Saxena, BM Shields, P Shrader, G Sigurdsson, T Sparsø, K Strassburger, HM Stringham, Q Sun, AJ Swift, B Thorand, J Tichet, T Tuomi, RM van Dam, TW van Haeften, T van Herpt, JV van Vliet-Ostaptchouk, GB Walters, MN Weedon, C Wijmenga, J Witteman, RN Bergman, S Cauchi, FS Collins, AL Gloyn, U Gyllensten, T Hansen, WA Hide, GA Hitman, A Hofman, DJ Hunter, K Hveem, M Laakso, KL Mohlke, AD Morris, CN Palmer, PP Pramstaller, I Rudan, E Sijbrands, LD Stein, J Tuomilehto, A Uitterlinden, M Walker, NJ Wareham, RM Watanabe, GR Abecasis, BO Boehm, H Campbell, MJ Daly, AT Hattersley, FB Hu, JB Meigs, JS Pankow, O Pedersen, HE Wichmann, I Barroso, JC Florez, TM Frayling, L Groop, R Sladek, U Thorsteinsdottir, JF Wilson, T Illig, P Froguel, CM van Duijn, K Stefansson, D Altshuler, M Boehnke, MI McCarthy

TITLE:

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.

JOURNAL:

Nature genetics Jul 2010, Vol 42, pp. 579-89

ABSTRACT:

By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D) and 38,987 controls of European descent and following up previously unidentified meta-analysis signals in a further 34,412 cases and 59,925 controls, we identified 12 new T2D association signals with combined P<5x10(-8). These include a second independent signal at the KCNQ1 locus; the first report, to our knowledge, of an X-chromosomal association (near DUSP9); and a further instance of overlap between loci implicated in monogenic and multifactorial forms of diabetes (at HNF1A). The identified loci affect both beta-cell function and insulin action, and, overall, T2D association signals show evidence of enrichment for genes involved in cell cycle regulation. We also show that a high proportion of T2D susceptibility loci harbor independent association signals influencing apparently unrelated complex traits. PUBMED: 20581827
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