DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Factor VIII levels. The EFO term factor VIII measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: factor VIII measurement

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

NL Smith, MH Chen, A Dehghan, DP Strachan, S Basu, N Soranzo, C Hayward, I Rudan, M Sabater-Lleal, JC Bis, MP de Maat, A Rumley, X Kong, Q Yang, FM Williams, V Vitart, H Campbell, A Mälarstig, KL Wiggins, CM Van Duijn, WL McArdle, JS Pankow, AD Johnson, A Silveira, B McKnight, AG Uitterlinden, N Aleksic, JB Meigs, A Peters, W Koenig, M Cushman, S Kathiresan, JI Rotter, EG Bovill, A Hofman, E Boerwinkle, GH Tofler, JF Peden, BM Psaty, F Leebeek, AR Folsom, MG Larson, TD Spector, AF Wright, JF Wilson, A Hamsten, T Lumley, JC Witteman, W Tang, CJ O'Donnell

TITLE:

Novel associations of multiple genetic loci with plasma levels of factor VII, factor VIII, and von Willebrand factor: The CHARGE (Cohorts for Heart and Aging Research in Genome Epidemiology) Consortium.

JOURNAL:

Circulation Mar 2010, Vol 121, pp. 1382-92

ABSTRACT:

Plasma levels of coagulation factors VII (FVII), VIII (FVIII), and von Willebrand factor (vWF) influence risk of hemorrhage and thrombosis. We conducted genome-wide association studies to identify new loci associated with plasma levels. PUBMED: 20231535
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