DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Menopause (age at onset). The EFO term age at menopause was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: age at menopause

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

L Stolk, JR Perry, DI Chasman, C He, M Mangino, P Sulem, M Barbalic, L Broer, EM Byrne, F Ernst, T Esko, N Franceschini, DF Gudbjartsson, JJ Hottenga, P Kraft, PF McArdle, E Porcu, SY Shin, AV Smith, S van Wingerden, G Zhai, WV Zhuang, E Albrecht, BZ Alizadeh, T Aspelund, S Bandinelli, LB Lauc, JS Beckmann, M Boban, E Boerwinkle, FJ Broekmans, A Burri, H Campbell, SJ Chanock, C Chen, MC Cornelis, T Corre, AD Coviello, P d'Adamo, G Davies, U de Faire, EJ de Geus, IJ Deary, GV Dedoussis, P Deloukas, S Ebrahim, G Eiriksdottir, V Emilsson, JG Eriksson, BC Fauser, L Ferreli, L Ferrucci, K Fischer, AR Folsom, ME Garcia, P Gasparini, C Gieger, N Glazer, DE Grobbee, P Hall, T Haller, SE Hankinson, M Hass, C Hayward, AC Heath, A Hofman, E Ingelsson, AC Janssens, AD Johnson, D Karasik, SL Kardia, J Keyzer, DP Kiel, I Kolcic, Z Kutalik, J Lahti, S Lai, T Laisk, JS Laven, DA Lawlor, J Liu, LM Lopez, YV Louwers, PK Magnusson, M Marongiu, NG Martin, IM Klaric, C Masciullo, B McKnight, SE Medland, D Melzer, V Mooser, P Navarro, AB Newman, DR Nyholt, NC Onland-Moret, A Palotie, G Paré, AN Parker, NL Pedersen, PH Peeters, G Pistis, AS Plump, O Polasek, VJ Pop, BM Psaty, K Räikkönen, E Rehnberg, JI Rotter, I Rudan, C Sala, A Salumets, A Scuteri, A Singleton, JA Smith, H Snieder, N Soranzo, SN Stacey, JM Starr, MG Stathopoulou, K Stirrups, RP Stolk, U Styrkarsdottir, YV Sun, A Tenesa, B Thorand, D Toniolo, L Tryggvadottir, K Tsui, S Ulivi, RM van Dam, YT van der Schouw, CH van Gils, P van Nierop, JM Vink, PM Visscher, M Voorhuis, G Waeber, H Wallaschofski, HE Wichmann, E Widen, CJ Wijnands-van Gent, G Willemsen, JF Wilson, BH Wolffenbuttel, AF Wright, LM Yerges-Armstrong, T Zemunik, L Zgaga, MC Zillikens, M Zygmunt, AM Arnold, DI Boomsma, JE Buring, L Crisponi, EW Demerath, V Gudnason, TB Harris, FB Hu, DJ Hunter, LJ Launer, A Metspalu, GW Montgomery, BA Oostra, PM Ridker, S Sanna, D Schlessinger, TD Spector, K Stefansson, EA Streeten, U Thorsteinsdottir, M Uda, AG Uitterlinden, CM van Duijn, H Völzke, A Murray, JM Murabito, JA Visser, KL Lunetta

TITLE:

Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.

JOURNAL:

Nature genetics Jan 2012, Vol 44, pp. 260-8

ABSTRACT:

To newly identify loci for age at natural menopause, we carried out a meta-analysis of 22 genome-wide association studies (GWAS) in 38,968 women of European descent, with replication in up to 14,435 women. In addition to four known loci, we identified 13 loci newly associated with age at natural menopause (at P < 5 × 10(-8)). Candidate genes located at these newly associated loci include genes implicated in DNA repair (EXO1, HELQ, UIMC1, FAM175A, FANCI, TLK1, POLG and PRIM1) and immune function (IL11, NLRP11 and PRRC2A (also known as BAT2)). Gene-set enrichment pathway analyses using the full GWAS data set identified exoDNase, NF-κB signaling and mitochondrial dysfunction as biological processes related to timing of menopause. PUBMED: 22267201
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