DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Developmental language disorder (linguistic errors). The EFO term linguistic error measurement, specific language impairment was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: linguistic error measurement, specific language impairment

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

SA Kornilov, N Rakhlin, R Koposov, M Lee, C Yrigollen, AO Caglayan, JS Magnuson, S Mane, JT Chang, EL Grigorenko

TITLE:

Genome-Wide Association and Exome Sequencing Study of Language Disorder in an Isolated Population.

JOURNAL:

Pediatrics Apr 2016, Vol 137, pp. None

ABSTRACT:

Developmental language disorder (DLD) is a highly prevalent neurodevelopmental disorder associated with negative outcomes in different domains; the etiology of DLD is unknown. To investigate the genetic underpinnings of DLD, we performed genome-wide association and whole exome sequencing studies in a geographically isolated population with a substantially elevated prevalence of the disorder (ie, the AZ sample). PUBMED: 27016271
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