GeneSet Information

Tier I GS269340 • GWAS Catalog Data for body height in 253,288 European ancestry individuals

DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Height. The EFO term body height was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: body height

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

AR Wood, T Esko, J Yang, S Vedantam, TH Pers, S Gustafsson, AY Chu, K Estrada, J Luan, Z Kutalik, N Amin, ML Buchkovich, DC Croteau-Chonka, FR Day, Y Duan, T Fall, R Fehrmann, T Ferreira, AU Jackson, J Karjalainen, KS Lo, AE Locke, R Mägi, E Mihailov, E Porcu, JC Randall, A Scherag, AA Vinkhuyzen, HJ Westra, TW Winkler, T Workalemahu, JH Zhao, D Absher, E Albrecht, D Anderson, J Baron, M Beekman, A Demirkan, GB Ehret, B Feenstra, MF Feitosa, K Fischer, RM Fraser, A Goel, J Gong, AE Justice, S Kanoni, ME Kleber, K Kristiansson, U Lim, V Lotay, JC Lui, M Mangino, I Mateo Leach, C Medina-Gomez, MA Nalls, DR Nyholt, CD Palmer, D Pasko, S Pechlivanis, I Prokopenko, JS Ried, S Ripke, D Shungin, A Stancáková, RJ Strawbridge, YJ Sung, T Tanaka, A Teumer, S Trompet, SW van der Laan, J van Setten, JV Van Vliet-Ostaptchouk, Z Wang, L Yengo, W Zhang, U Afzal, J Arnlöv, GM Arscott, S Bandinelli, A Barrett, C Bellis, AJ Bennett, C Berne, M Blüher, JL Bolton, Y Böttcher, HA Boyd, M Bruinenberg, BM Buckley, S Buyske, IH Caspersen, PS Chines, R Clarke, S Claudi-Boehm, M Cooper, EW Daw, PA De Jong, J Deelen, G Delgado, JC Denny, R Dhonukshe-Rutten, M Dimitriou, AS Doney, M Dörr, N Eklund, E Eury, L Folkersen, ME Garcia, F Geller, V Giedraitis, AS Go, H Grallert, TB Grammer, J Gräßler, H Grönberg, LC de Groot, CJ Groves, J Haessler, P Hall, T Haller, G Hallmans, A Hannemann, CA Hartman, M Hassinen, C Hayward, NL Heard-Costa, Q Helmer, G Hemani, AK Henders, HL Hillege, MA Hlatky, W Hoffmann, P Hoffmann, O Holmen, JJ Houwing-Duistermaat, T Illig, A Isaacs, AL James, J Jeff, B Johansen, Å Johansson, J Jolley, T Juliusdottir, J Junttila, AN Kho, L Kinnunen, N Klopp, T Kocher, W Kratzer, P Lichtner, L Lind, J Lindström, S Lobbens, M Lorentzon, Y Lu, V Lyssenko, PK Magnusson, A Mahajan, M Maillard, WL McArdle, CA McKenzie, S McLachlan, PJ McLaren, C Menni, S Merger, L Milani, A Moayyeri, KL Monda, MA Morken, G Müller, M Müller-Nurasyid, AW Musk, N Narisu, M Nauck, IM Nolte, MM Nöthen, L Oozageer, S Pilz, NW Rayner, F Renstrom, NR Robertson, LM Rose, R Roussel, S Sanna, H Scharnagl, S Scholtens, FR Schumacher, H Schunkert, RA Scott, J Sehmi, T Seufferlein, J Shi, K Silventoinen, JH Smit, AV Smith, J Smolonska, AV Stanton, K Stirrups, DJ Stott, HM Stringham, J Sundström, MA Swertz, AC Syvänen, BO Tayo, G Thorleifsson, JP Tyrer, S van Dijk, NM van Schoor, N van der Velde, D van Heemst, FV van Oort, SH Vermeulen, N Verweij, JM Vonk, LL Waite, M Waldenberger, R Wennauer, LR Wilkens, C Willenborg, T Wilsgaard, MK Wojczynski, A Wong, AF Wright, Q Zhang, D Arveiler, SJ Bakker, J Beilby, RN Bergman, S Bergmann, R Biffar, J Blangero, DI Boomsma, SR Bornstein, P Bovet, P Brambilla, MJ Brown, H Campbell, MJ Caulfield, A Chakravarti, R Collins, FS Collins, DC Crawford, LA Cupples, J Danesh, U de Faire, HM den Ruijter, R Erbel, J Erdmann, JG Eriksson, M Farrall, E Ferrannini, J Ferrières, I Ford, NG Forouhi, T Forrester, RT Gansevoort, PV Gejman, C Gieger, A Golay, O Gottesman, V Gudnason, U Gyllensten, DW Haas, AS Hall, TB Harris, AT Hattersley, AC Heath, C Hengstenberg, AA Hicks, LA Hindorff, AD Hingorani, A Hofman, GK Hovingh, SE Humphries, SC Hunt, E Hypponen, KB Jacobs, MR Jarvelin, P Jousilahti, AM Jula, J Kaprio, JJ Kastelein, M Kayser, F Kee, SM Keinanen-Kiukaanniemi, LA Kiemeney, JS Kooner, C Kooperberg, S Koskinen, P Kovacs, AT Kraja, M Kumari, J Kuusisto, TA Lakka, C Langenberg, L Le Marchand, T Lehtimäki, S Lupoli, PA Madden, S Männistö, P Manunta, A Marette, TC Matise, B McKnight, T Meitinger, FL Moll, GW Montgomery, AD Morris, AP Morris, JC Murray, M Nelis, C Ohlsson, AJ Oldehinkel, KK Ong, WH Ouwehand, G Pasterkamp, A Peters, PP Pramstaller, JF Price, L Qi, OT Raitakari, T Rankinen, DC Rao, TK Rice, M Ritchie, I Rudan, V Salomaa, NJ Samani, J Saramies, MA Sarzynski, PE Schwarz, S Sebert, P Sever, AR Shuldiner, J Sinisalo, V Steinthorsdottir, RP Stolk, JC Tardif, A Tönjes, A Tremblay, E Tremoli, J Virtamo, MC Vohl, P Amouyel, FW Asselbergs, TL Assimes, M Bochud, BO Boehm, E Boerwinkle, EP Bottinger, C Bouchard, S Cauchi, JC Chambers, SJ Chanock, RS Cooper, PI de Bakker, G Dedoussis, L Ferrucci, PW Franks, P Froguel, LC Groop, CA Haiman, A Hamsten, MG Hayes, J Hui, DJ Hunter, K Hveem, JW Jukema, RC Kaplan, M Kivimaki, D Kuh, M Laakso, Y Liu, NG Martin, W März, M Melbye, S Moebus, PB Munroe, I Njølstad, BA Oostra, CN Palmer, NL Pedersen, M Perola, L Pérusse, U Peters, JE Powell, C Power, T Quertermous, R Rauramaa, E Reinmaa, PM Ridker, F Rivadeneira, JI Rotter, TE Saaristo, D Saleheen, D Schlessinger, PE Slagboom, H Snieder, TD Spector, K Strauch, M Stumvoll, J Tuomilehto, M Uusitupa, P van der Harst, H Völzke, M Walker, NJ Wareham, H Watkins, HE Wichmann, JF Wilson, P Zanen, P Deloukas, IM Heid, CM Lindgren, KL Mohlke, EK Speliotes, U Thorsteinsdottir, I Barroso, CS Fox, KE North, DP Strachan, JS Beckmann, SI Berndt, M Boehnke, IB Borecki, MI McCarthy, A Metspalu, K Stefansson, AG Uitterlinden, CM van Duijn, L Franke, CJ Willer, AL Price, G Lettre, RJ Loos, MN Weedon, E Ingelsson, JR O'Connell, GR Abecasis, DI Chasman, ME Goddard, PM Visscher, JN Hirschhorn, TM Frayling

TITLE:

Defining the role of common variation in the genomic and biological architecture of adult human height.

JOURNAL:

Nature genetics Nov 2014, Vol 46, pp. 1173-86

ABSTRACT:

Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated ∼2,000, ∼3,700 and ∼9,500 SNPs explained ∼21%, ∼24% and ∼29% of phenotypic variance. Furthermore, all common variants together captured 60% of heritability. The 697 variants clustered in 423 loci were enriched for genes, pathways and tissue types known to be involved in growth and together implicated genes and pathways not highlighted in earlier efforts, such as signaling by fibroblast growth factors, WNT/β-catenin and chondroitin sulfate-related genes. We identified several genes and pathways not previously connected with human skeletal growth, including mTOR, osteoglycin and binding of hyaluronic acid. Our results indicate a genetic architecture for human height that is characterized by a very large but finite number (thousands) of causal variants. PUBMED: 25282103
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Annotation Information

No sequence read archive data associated with this GeneSet.


body height (EFO:0004339)

Gene List • 219 Genes

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