DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Breast cancer. The EFO term breast carcinoma was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: breast carcinoma

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

AC Antoniou, X Wang, ZS Fredericksen, L McGuffog, R Tarrell, OM Sinilnikova, S Healey, J Morrison, C Kartsonaki, T Lesnick, M Ghoussaini, D Barrowdale, S Peock, M Cook, C Oliver, D Frost, D Eccles, DG Evans, R Eeles, L Izatt, C Chu, F Douglas, J Paterson, D Stoppa-Lyonnet, C Houdayer, S Mazoyer, S Giraud, C Lasset, A Remenieras, O Caron, A Hardouin, P Berthet, FB Hogervorst, MA Rookus, A Jager, A van den Ouweland, N Hoogerbrugge, RB van der Luijt, H Meijers-Heijboer, EB Gómez García, P Devilee, MP Vreeswijk, J Lubinski, A Jakubowska, J Gronwald, T Huzarski, T Byrski, B Górski, C Cybulski, AB Spurdle, H Holland, DE Goldgar, EM John, JL Hopper, M Southey, SS Buys, MB Daly, MB Terry, RK Schmutzler, B Wappenschmidt, C Engel, A Meindl, S Preisler-Adams, N Arnold, D Niederacher, C Sutter, SM Domchek, KL Nathanson, T Rebbeck, JL Blum, M Piedmonte, GC Rodriguez, K Wakeley, JF Boggess, J Basil, SV Blank, E Friedman, B Kaufman, Y Laitman, R Milgrom, IL Andrulis, G Glendon, H Ozcelik, T Kirchhoff, J Vijai, MM Gaudet, D Altshuler, C Guiducci, N Loman, K Harbst, J Rantala, H Ehrencrona, AM Gerdes, M Thomassen, L Sunde, P Peterlongo, S Manoukian, B Bonanni, A Viel, P Radice, T Caldes, M de la Hoya, CF Singer, A Fink-Retter, MH Greene, PL Mai, JT Loud, L Guidugli, NM Lindor, TV Hansen, FC Nielsen, I Blanco, C Lazaro, J Garber, SJ Ramus, SA Gayther, C Phelan, S Narod, CI Szabo, J Benitez, A Osorio, H Nevanlinna, T Heikkinen, MA Caligo, MS Beattie, U Hamann, AK Godwin, M Montagna, C Casella, SL Neuhausen, BY Karlan, N Tung, AE Toland, J Weitzel, O Olopade, J Simard, P Soucy, WS Rubinstein, A Arason, G Rennert, NG Martin, GW Montgomery, J Chang-Claude, D Flesch-Janys, H Brauch, G Severi, L Baglietto, A Cox, SS Cross, P Miron, SM Gerty, W Tapper, D Yannoukakos, G Fountzilas, PA Fasching, MW Beckmann, I Dos Santos Silva, J Peto, D Lambrechts, R Paridaens, T Rüdiger, A Försti, R Winqvist, K Pylkäs, RB Diasio, AM Lee, J Eckel-Passow, C Vachon, F Blows, K Driver, A Dunning, PP Pharoah, K Offit, VS Pankratz, H Hakonarson, G Chenevix-Trench, DF Easton, FJ Couch

TITLE:

A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population.

JOURNAL:

Nature genetics Oct 2010, Vol 42, pp. 885-92

ABSTRACT:

Germline BRCA1 mutations predispose to breast cancer. To identify genetic modifiers of this risk, we performed a genome-wide association study in 1,193 individuals with BRCA1 mutations who were diagnosed with invasive breast cancer under age 40 and 1,190 BRCA1 carriers without breast cancer diagnosis over age 35. We took forward 96 SNPs for replication in another 5,986 BRCA1 carriers (2,974 individuals with breast cancer and 3,012 unaffected individuals). Five SNPs on 19p13 were associated with breast cancer risk (P(trend) = 2.3 × 10⁻⁹ to P(trend) = 3.9 × 10⁻⁷), two of which showed independent associations (rs8170, hazard ratio (HR) = 1.26, 95% CI 1.17-1.35; rs2363956 HR = 0.84, 95% CI 0.80-0.89). Genotyping these SNPs in 6,800 population-based breast cancer cases and 6,613 controls identified a similar association with estrogen receptor-negative breast cancer (rs2363956 per-allele odds ratio (OR) = 0.83, 95% CI 0.75-0.92, P(trend) = 0.0003) and an association with estrogen receptor-positive disease in the opposite direction (OR = 1.07, 95% CI 1.01-1.14, P(trend) = 0.016). The five SNPs were also associated with triple-negative breast cancer in a separate study of 2,301 triple-negative cases and 3,949 controls (P(trend) = 1 × 10⁻⁷) to P(trend) = 8 × 10⁻⁵; rs2363956 per-allele OR = 0.80, 95% CI 0.74-0.87, P(trend) = 1.1 × 10⁻⁷ PUBMED: 20852631
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