DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Homocysteine levels. The EFO term homocysteine measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: homocysteine measurement

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

JB van Meurs, G Pare, SM Schwartz, A Hazra, T Tanaka, SH Vermeulen, I Cotlarciuc, X Yuan, A Mälarstig, S Bandinelli, JC Bis, H Blom, MJ Brown, C Chen, YD Chen, RJ Clarke, A Dehghan, J Erdmann, L Ferrucci, A Hamsten, A Hofman, DJ Hunter, A Goel, AD Johnson, S Kathiresan, E Kampman, DP Kiel, LA Kiemeney, JC Chambers, P Kraft, J Lindemans, B McKnight, CP Nelson, CJ O'Donnell, BM Psaty, PM Ridker, F Rivadeneira, LM Rose, U Seedorf, DS Siscovick, H Schunkert, J Selhub, PM Ueland, P Vollenweider, G Waeber, DM Waterworth, H Watkins, JC Witteman, M den Heijer, P Jacques, AG Uitterlinden, JS Kooner, DJ Rader, MP Reilly, V Mooser, DI Chasman, NJ Samani, KR Ahmadi

TITLE:

Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease.

JOURNAL:

The American journal of clinical nutrition Sep 2013, Vol 98, pp. 668-76

ABSTRACT:

The strong observational association between total homocysteine (tHcy) concentrations and risk of coronary artery disease (CAD) and the null associations in the homocysteine-lowering trials have prompted the need to identify genetic variants associated with homocysteine concentrations and risk of CAD. PUBMED: 23824729
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