DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Major depressive disorder. The EFO term unipolar depression was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: unipolar depression

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

RA Power, KE Tansey, HN Buttenschøn, S Cohen-Woods, T Bigdeli, LS Hall, Z Kutalik, SH Lee, S Ripke, S Steinberg, A Teumer, A Viktorin, NR Wray, V Arolt, BT Baune, DI Boomsma, AD Børglum, EM Byrne, E Castelao, N Craddock, IW Craig, U Dannlowski, IJ Deary, F Degenhardt, AJ Forstner, SD Gordon, HJ Grabe, J Grove, SP Hamilton, C Hayward, AC Heath, LJ Hocking, G Homuth, JJ Hottenga, S Kloiber, J Krogh, M Landén, M Lang, DF Levinson, P Lichtenstein, S Lucae, DJ MacIntyre, P Madden, PK Magnusson, NG Martin, AM McIntosh, CM Middeldorp, Y Milaneschi, GW Montgomery, O Mors, B Müller-Myhsok, DR Nyholt, H Oskarsson, MJ Owen, S Padmanabhan, BW Penninx, ML Pergadia, DJ Porteous, JB Potash, M Preisig, M Rivera, J Shi, SI Shyn, E Sigurdsson, JH Smit, BH Smith, H Stefansson, K Stefansson, J Strohmaier, PF Sullivan, P Thomson, TE Thorgeirsson, S Van der Auwera, MM Weissman, G Breen, CM Lewis

TITLE:

Genome-wide Association for Major Depression Through Age at Onset Stratification: Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium.

JOURNAL:

Biological psychiatry Feb 2017, Vol 81, pp. 325-335

ABSTRACT:

Major depressive disorder (MDD) is a disabling mood disorder, and despite a known heritable component, a large meta-analysis of genome-wide association studies revealed no replicable genetic risk variants. Given prior evidence of heterogeneity by age at onset in MDD, we tested whether genome-wide significant risk variants for MDD could be identified in cases subdivided by age at onset. PUBMED: 27519822
Find other GeneSets from this publication