DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was IgA nephropathy. The EFO term IGA glomerulonephritis was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: IGA glomerulonephritis

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

K Kiryluk, Y Li, F Scolari, S Sanna-Cherchi, M Choi, M Verbitsky, D Fasel, S Lata, S Prakash, S Shapiro, C Fischman, HJ Snyder, G Appel, C Izzi, BF Viola, N Dallera, L Del Vecchio, C Barlassina, E Salvi, FE Bertinetto, A Amoroso, S Savoldi, M Rocchietti, A Amore, L Peruzzi, R Coppo, M Salvadori, P Ravani, R Magistroni, GM Ghiggeri, G Caridi, M Bodria, F Lugani, L Allegri, M Delsante, M Maiorana, A Magnano, G Frasca, E Boer, G Boscutti, C Ponticelli, R Mignani, C Marcantoni, D Di Landro, D Santoro, A Pani, R Polci, S Feriozzi, S Chicca, M Galliani, M Gigante, L Gesualdo, P Zamboli, GG Battaglia, M Garozzo, D Maixnerová, V Tesar, F Eitner, T Rauen, J Floege, T Kovacs, J Nagy, K Mucha, L Pączek, M Zaniew, M Mizerska-Wasiak, M Roszkowska-Blaim, K Pawlaczyk, D Gale, J Barratt, L Thibaudin, F Berthoux, G Canaud, A Boland, M Metzger, U Panzer, H Suzuki, S Goto, I Narita, Y Caliskan, J Xie, P Hou, N Chen, H Zhang, RJ Wyatt, J Novak, BA Julian, J Feehally, B Stengel, D Cusi, RP Lifton, AG Gharavi

TITLE:

Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens.

JOURNAL:

Nature genetics Nov 2014, Vol 46, pp. 1187-96

ABSTRACT:

We performed a genome-wide association study (GWAS) of IgA nephropathy (IgAN), the most common form of glomerulonephritis, with discovery and follow-up in 20,612 individuals of European and East Asian ancestry. We identified six new genome-wide significant associations, four in ITGAM-ITGAX, VAV3 and CARD9 and two new independent signals at HLA-DQB1 and DEFA. We replicated the nine previously reported signals, including known SNPs in the HLA-DQB1 and DEFA loci. The cumulative burden of risk alleles is strongly associated with age at disease onset. Most loci are either directly associated with risk of inflammatory bowel disease (IBD) or maintenance of the intestinal epithelial barrier and response to mucosal pathogens. The geospatial distribution of risk alleles is highly suggestive of multi-locus adaptation, and genetic risk correlates strongly with variation in local pathogens, particularly helminth diversity, suggesting a possible role for host-intestinal pathogen interactions in shaping the genetic landscape of IgAN. PUBMED: 25305756
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