DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Prostate-specific antigen levels. The EFO term prostate specific antigen measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: prostate specific antigen measurement

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

G Jin, SL Zheng, H Lilja, ST Kim, S Tao, Z Gao, T Young, F Wiklund, J Feng, WB Isaacs, RS Rittmaster, H Gronberg, LD Condreay, J Sun, J Xu

TITLE:

Genome-wide association study identifies loci at ATF7IP and KLK2 associated with percentage of circulating free PSA.

JOURNAL:

Neoplasia (New York, N.Y.) Jan 2013, Vol 15, pp. 95-101

ABSTRACT:

Percentage of free-to-total prostate-specific antigen (%fPSA) is an independent predictor of risk for prostate cancer among men with modestly elevated level of total PSA (tPSA) in blood. Physiological and pathological factors have been shown to influence the %fPSA value and diagnostic accuracy. PUBMED: 23359319
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