DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Celiac disease. The EFO term celiac disease was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: celiac disease

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

DA van Heel, L Franke, KA Hunt, R Gwilliam, A Zhernakova, M Inouye, MC Wapenaar, MC Barnardo, G Bethel, GK Holmes, C Feighery, D Jewell, D Kelleher, P Kumar, S Travis, JR Walters, DS Sanders, P Howdle, J Swift, RJ Playford, WM McLaren, ML Mearin, CJ Mulder, R McManus, R McGinnis, LR Cardon, P Deloukas, C Wijmenga

TITLE:

A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21.

JOURNAL:

Nature genetics Jul 2007, Vol 39, pp. 827-9

ABSTRACT:

We tested 310,605 SNPs for association in 778 individuals with celiac disease and 1,422 controls. Outside the HLA region, the most significant finding (rs13119723; P = 2.0 x 10(-7)) was in the KIAA1109-TENR-IL2-IL21 linkage disequilibrium block. We independently confirmed association in two further collections (strongest association at rs6822844, 24 kb 5' of IL21; meta-analysis P = 1.3 x 10(-14), odds ratio = 0.63), suggesting that genetic variation in this region predisposes to celiac disease. PUBMED: 17558408
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