DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Arterial stiffness. The EFO term arterial stiffness measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: arterial stiffness measurement

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

KV Tarasov, S Sanna, A Scuteri, JB Strait, M Orrù, A Parsa, PI Lin, A Maschio, S Lai, MG Piras, M Masala, T Tanaka, W Post, JR O'Connell, D Schlessinger, A Cao, R Nagaraja, BD Mitchell, GR Abecasis, AR Shuldiner, M Uda, EG Lakatta, SS Najjar

TITLE:

COL4A1 is associated with arterial stiffness by genome-wide association scan.

JOURNAL:

Circulation. Cardiovascular genetics Apr 2009, Vol 2, pp. 151-8

ABSTRACT:

Pulse wave velocity (PWV), a noninvasive index of central arterial stiffness, is a potent predictor of cardiovascular mortality and morbidity. Heritability and linkage studies have pointed toward a genetic component affecting PWV. We conducted a genome-wide association study to identify single-nucleotide polymorphisms (SNPs) associated with PWV. PUBMED: 20031579
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