DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Asymmetrical dimethylarginine levels. The EFO term asymmetrical dimethylarginine measurement, serum dimethylarginine measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: asymmetrical dimethylarginine measurement, serum dimethylarginine measurement

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

I Seppälä, ME Kleber, LP Lyytikäinen, JA Hernesniemi, KM Mäkelä, N Oksala, R Laaksonen, S Pilz, A Tomaschitz, G Silbernagel, BO Boehm, TB Grammer, T Koskinen, M Juonala, N Hutri-Kähönen, G Alfthan, JS Viikari, M Kähonen, OT Raitakari, W März, A Meinitzer, T Lehtimäki

TITLE:

Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.

JOURNAL:

European heart journal Feb 2014, Vol 35, pp. 524-31

ABSTRACT:

The purpose of this study was to identify novel genetic variants influencing circulating asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) levels and to evaluate whether they have a prognostic value on cardiovascular mortality. PUBMED: 24159190
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