DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Symmetrical dimethylarginine levels. The EFO term serum dimethylarginine measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: serum dimethylarginine measurement

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

I Seppälä, ME Kleber, LP Lyytikäinen, JA Hernesniemi, KM Mäkelä, N Oksala, R Laaksonen, S Pilz, A Tomaschitz, G Silbernagel, BO Boehm, TB Grammer, T Koskinen, M Juonala, N Hutri-Kähönen, G Alfthan, JS Viikari, M Kähonen, OT Raitakari, W März, A Meinitzer, T Lehtimäki

TITLE:

Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.

JOURNAL:

European heart journal Feb 2014, Vol 35, pp. 524-31

ABSTRACT:

The purpose of this study was to identify novel genetic variants influencing circulating asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) levels and to evaluate whether they have a prognostic value on cardiovascular mortality. PUBMED: 24159190
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