DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Neuroticism. The EFO term neuroticism measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: neuroticism measurement

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

A Okbay, BM Baselmans, JE De Neve, P Turley, MG Nivard, MA Fontana, SF Meddens, RK Linnér, CA Rietveld, J Derringer, J Gratten, JJ Lee, JZ Liu, R de Vlaming, TS Ahluwalia, J Buchwald, A Cavadino, AC Frazier-Wood, NA Furlotte, V Garfield, MH Geisel, JR Gonzalez, S Haitjema, R Karlsson, SW van der Laan, KH Ladwig, J Lahti, SJ van der Lee, PA Lind, T Liu, L Matteson, E Mihailov, MB Miller, CC Minica, IM Nolte, D Mook-Kanamori, PJ van der Most, C Oldmeadow, Y Qian, O Raitakari, R Rawal, A Realo, R Rueedi, B Schmidt, AV Smith, E Stergiakouli, T Tanaka, K Taylor, J Wedenoja, J Wellmann, HJ Westra, SM Willems, W Zhao, N Amin, A Bakshi, PA Boyle, S Cherney, SR Cox, G Davies, OS Davis, J Ding, N Direk, P Eibich, RT Emeny, G Fatemifar, JD Faul, L Ferrucci, A Forstner, C Gieger, R Gupta, TB Harris, JM Harris, EG Holliday, JJ Hottenga, PL De Jager, MA Kaakinen, E Kajantie, V Karhunen, I Kolcic, M Kumari, LJ Launer, L Franke, R Li-Gao, M Koini, A Loukola, P Marques-Vidal, GW Montgomery, MA Mosing, L Paternoster, A Pattie, KE Petrovic, L Pulkki-Råback, L Quaye, K Räikkönen, I Rudan, RJ Scott, JA Smith, AR Sutin, M Trzaskowski, AE Vinkhuyzen, L Yu, D Zabaneh, JR Attia, DA Bennett, K Berger, L Bertram, DI Boomsma, H Snieder, SC Chang, F Cucca, IJ Deary, CM van Duijn, JG Eriksson, U Bültmann, EJ de Geus, PJ Groenen, V Gudnason, T Hansen, CA Hartman, CM Haworth, C Hayward, AC Heath, DA Hinds, E Hyppönen, WG Iacono, MR Järvelin, KH Jöckel, J Kaprio, SL Kardia, L Keltikangas-Järvinen, P Kraft, LD Kubzansky, T Lehtimäki, PK Magnusson, NG Martin, M McGue, A Metspalu, M Mills, R de Mutsert, AJ Oldehinkel, G Pasterkamp, NL Pedersen, R Plomin, O Polasek, C Power, SS Rich, FR Rosendaal, HM den Ruijter, D Schlessinger, H Schmidt, R Svento, R Schmidt, BZ Alizadeh, TI Sørensen, TD Spector, A Steptoe, A Terracciano, AR Thurik, NJ Timpson, H Tiemeier, AG Uitterlinden, P Vollenweider, GG Wagner, DR Weir, J Yang, DC Conley, GD Smith, A Hofman, M Johannesson, DI Laibson, SE Medland, MN Meyer, JK Pickrell, T Esko, RF Krueger, JP Beauchamp, PD Koellinger, DJ Benjamin, M Bartels, D Cesarini

TITLE:

Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.

JOURNAL:

Nature genetics Jun 2016, Vol 48, pp. 624-33

ABSTRACT:

Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (|ρ^| ≈ 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association. PUBMED: 27089181
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