DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Multiple sclerosis. The EFO term multiple sclerosis was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: multiple sclerosis

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

YS Aulchenko, IA Hoppenbrouwers, SV Ramagopalan, L Broer, N Jafari, J Hillert, J Link, W Lundström, E Greiner, A Dessa Sadovnick, D Goossens, C Van Broeckhoven, J Del-Favero, GC Ebers, BA Oostra, CM van Duijn, RQ Hintzen

TITLE:

Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis.

JOURNAL:

Nature genetics Dec 2008, Vol 40, pp. 1402-3

ABSTRACT:

The few loci associated with multiple sclerosis (MS) are all related to immune function. We report a GWA study identifying a new locus replicated in 2,679 cases and 3,125 controls. An rs10492972[C] variant located in the KIF1B gene was associated with MS with an odds ratio of 1.35 (P = 2.5 x 10(-10)). KIF1B is a neuronally expressed gene plausibly implicated in the irreversible axonal loss characterizing MS in the long term. PUBMED: 18997785
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