DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Childhood body mass index. The EFO term body mass index was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: body mass index

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

JF Felix, JP Bradfield, C Monnereau, RJ van der Valk, E Stergiakouli, A Chesi, R Gaillard, B Feenstra, E Thiering, E Kreiner-Møller, A Mahajan, N Pitkänen, R Joro, A Cavadino, V Huikari, S Franks, MM Groen-Blokhuis, DL Cousminer, JA Marsh, T Lehtimäki, JA Curtin, J Vioque, TS Ahluwalia, R Myhre, TS Price, N Vilor-Tejedor, L Yengo, N Grarup, I Ntalla, W Ang, M Atalay, H Bisgaard, AI Blakemore, A Bonnefond, L Carstensen, J Eriksson, C Flexeder, L Franke, F Geller, M Geserick, AL Hartikainen, CM Haworth, JN Hirschhorn, A Hofman, JC Holm, M Horikoshi, JJ Hottenga, J Huang, HN Kadarmideen, M Kähönen, W Kiess, HM Lakka, TA Lakka, AM Lewin, L Liang, LP Lyytikäinen, B Ma, P Magnus, SE McCormack, G McMahon, FD Mentch, CM Middeldorp, CS Murray, K Pahkala, TH Pers, R Pfäffle, DS Postma, C Power, A Simpson, V Sengpiel, CM Tiesler, M Torrent, AG Uitterlinden, JB van Meurs, R Vinding, J Waage, J Wardle, E Zeggini, BS Zemel, GV Dedoussis, O Pedersen, P Froguel, J Sunyer, R Plomin, B Jacobsson, T Hansen, JR Gonzalez, A Custovic, OT Raitakari, CE Pennell, E Widén, DI Boomsma, GH Koppelman, S Sebert, MR Järvelin, E Hyppönen, MI McCarthy, V Lindi, N Harri, A Körner, K Bønnelykke, J Heinrich, M Melbye, F Rivadeneira, H Hakonarson, SM Ring, GD Smith, TI Sørensen, NJ Timpson, SF Grant, VW Jaddoe

TITLE:

Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index.

JOURNAL:

Human molecular genetics Jan 2016, Vol 25, pp. 389-403

ABSTRACT:

A large number of genetic loci are associated with adult body mass index. However, the genetics of childhood body mass index are largely unknown. We performed a meta-analysis of genome-wide association studies of childhood body mass index, using sex- and age-adjusted standard deviation scores. We included 35 668 children from 20 studies in the discovery phase and 11 873 children from 13 studies in the replication phase. In total, 15 loci reached genome-wide significance (P-value < 5 × 10(-8)) in the joint discovery and replication analysis, of which 12 are previously identified loci in or close to ADCY3, GNPDA2, TMEM18, SEC16B, FAIM2, FTO, TFAP2B, TNNI3K, MC4R, GPR61, LMX1B and OLFM4 associated with adult body mass index or childhood obesity. We identified three novel loci: rs13253111 near ELP3, rs8092503 near RAB27B and rs13387838 near ADAM23. Per additional risk allele, body mass index increased 0.04 Standard Deviation Score (SDS) [Standard Error (SE) 0.007], 0.05 SDS (SE 0.008) and 0.14 SDS (SE 0.025), for rs13253111, rs8092503 and rs13387838, respectively. A genetic risk score combining all 15 SNPs showed that each additional average risk allele was associated with a 0.073 SDS (SE 0.011, P-value = 3.12 × 10(-10)) increase in childhood body mass index in a population of 1955 children. This risk score explained 2% of the variance in childhood body mass index. This study highlights the shared genetic background between childhood and adult body mass index and adds three novel loci. These loci likely represent age-related differences in strength of the associations with body mass index. PUBMED: 26604143
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