DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Susceptibility to persistent hepatitis B virus infection. The EFO term hepatitis B infection, Susceptibility to viral and mycobacterial infections was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: hepatitis B infection, Susceptibility to viral and mycobacterial infections

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Y Li, L Si, Y Zhai, Y Hu, Z Hu, JX Bei, B Xie, Q Ren, P Cao, F Yang, Q Song, Z Bao, H Zhang, Y Han, Z Wang, X Chen, X Xia, H Yan, R Wang, Y Zhang, C Gao, J Meng, X Tu, X Liang, Y Cui, Y Liu, X Wu, Z Li, H Wang, Z Li, B Hu, M He, Z Gao, X Xu, H Ji, C Yu, Y Sun, B Xing, X Yang, H Zhang, A Tan, C Wu, W Jia, S Li, YX Zeng, H Shen, F He, Z Mo, H Zhang, G Zhou

TITLE:

Genome-wide association study identifies 8p21.3 associated with persistent hepatitis B virus infection among Chinese.

JOURNAL:

Nature communications May 2016, Vol 7, pp. 11664

ABSTRACT:

Hepatitis B virus (HBV) infection is a common infectious disease. Here we perform a genome-wide association study (GWAS) among Chinese populations to identify novel genetic loci involved in persistent HBV infection. GWAS scan is performed in 1,251 persistently HBV infected subjects (PIs, cases) and 1,057 spontaneously recovered subjects (SRs, controls), followed by replications in four independent populations totally consisting of 3,905 PIs and 3,356 SRs. We identify a novel locus at 8p21.3 (index rs7000921, odds ratio=0.78, P=3.2 × 10(-12)). Furthermore, we identify significant expression quantitative trait locus associations for INTS10 gene at 8p21.3. We demonstrate that INST10 suppresses HBV replication via IRF3 in liver cells. In clinical plasma samples, we confirm that INST10 levels are significantly decreased in PIs compared with SRs, and negatively correlated with the HBV load. These findings highlight a novel antiviral gene INTS10 at 8p21.3 in the clearance of HBV infection. PUBMED: 27244555
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