DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Airway hyperresponsiveness. The EFO term airway hyperresponsiveness was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: airway hyperresponsiveness

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

BE Himes, W Qiu, B Klanderman, J Ziniti, J Senter-Sylvia, SJ Szefler, RF Lemanske, RS Zeiger, RC Strunk, FD Martinez, H Boushey, VM Chinchilli, E Israel, D Mauger, GH Koppelman, MA Nieuwenhuis, DS Postma, JM Vonk, N Rafaels, NN Hansel, K Barnes, B Raby, KG Tantisira, ST Weiss

TITLE:

ITGB5 and AGFG1 variants are associated with severity of airway responsiveness.

JOURNAL:

BMC medical genetics Aug 2013, Vol 14, pp. 86

ABSTRACT:

Airway hyperresponsiveness (AHR), a primary characteristic of asthma, involves increased airway smooth muscle contractility in response to certain exposures. We sought to determine whether common genetic variants were associated with AHR severity. PUBMED: 23984888
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