DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Longevity (90 years and older). The EFO term longevity was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: longevity

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

L Broer, AS Buchman, J Deelen, DS Evans, JD Faul, KL Lunetta, P Sebastiani, JA Smith, AV Smith, T Tanaka, L Yu, AM Arnold, T Aspelund, EJ Benjamin, PL De Jager, G Eirkisdottir, DA Evans, ME Garcia, A Hofman, RC Kaplan, SL Kardia, DP Kiel, BA Oostra, ES Orwoll, N Parimi, BM Psaty, F Rivadeneira, JI Rotter, S Seshadri, A Singleton, H Tiemeier, AG Uitterlinden, W Zhao, S Bandinelli, DA Bennett, L Ferrucci, V Gudnason, TB Harris, D Karasik, LJ Launer, TT Perls, PE Slagboom, GJ Tranah, DR Weir, AB Newman, CM van Duijn, JM Murabito

TITLE:

GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy.

JOURNAL:

The journals of gerontology. Series A, Biological sciences and medical sciences Jan 2015, Vol 70, pp. 110-8

ABSTRACT:

The genetic contribution to longevity in humans has been estimated to range from 15% to 25%. Only two genes, APOE and FOXO3, have shown association with longevity in multiple independent studies. PUBMED: 25199915
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