DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Pulmonary function. The EFO term pulmonary function measurement, forced expiratory volume was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: pulmonary function measurement, forced expiratory volume

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

DB Hancock, M Eijgelsheim, JB Wilk, SA Gharib, LR Loehr, KD Marciante, N Franceschini, YM van Durme, TH Chen, RG Barr, MB Schabath, DJ Couper, GG Brusselle, BM Psaty, CM van Duijn, JI Rotter, AG Uitterlinden, A Hofman, NM Punjabi, F Rivadeneira, AC Morrison, PL Enright, KE North, SR Heckbert, T Lumley, BH Stricker, GT O'Connor, SJ London

TITLE:

Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function.

JOURNAL:

Nature genetics Jan 2010, Vol 42, pp. 45-52

ABSTRACT:

Spirometric measures of lung function are heritable traits that reflect respiratory health and predict morbidity and mortality. We meta-analyzed genome-wide association studies for two clinically important lung-function measures: forced expiratory volume in the first second (FEV(1)) and its ratio to forced vital capacity (FEV(1)/FVC), an indicator of airflow obstruction. This meta-analysis included 20,890 participants of European ancestry from four CHARGE Consortium studies: Atherosclerosis Risk in Communities, Cardiovascular Health Study, Framingham Heart Study and Rotterdam Study. We identified eight loci associated with FEV(1)/FVC (HHIP, GPR126, ADAM19, AGER-PPT2, FAM13A, PTCH1, PID1 and HTR4) and one locus associated with FEV(1) (INTS12-GSTCD-NPNT) at or near genome-wide significance (P < 5 x 10(-8)) in the CHARGE Consortium dataset. Our findings may offer insights into pulmonary function and pathogenesis of chronic lung disease. PUBMED: 20010835
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