DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Chronic lymphocytic leukemia. The EFO term chronic lymphocytic leukemia was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: chronic lymphocytic leukemia

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

SI Berndt, NJ Camp, CF Skibola, J Vijai, Z Wang, J Gu, A Nieters, RS Kelly, KE Smedby, A Monnereau, W Cozen, A Cox, SS Wang, Q Lan, LR Teras, M Machado, M Yeager, AR Brooks-Wilson, P Hartge, MP Purdue, BM Birmann, CM Vajdic, P Cocco, Y Zhang, GG Giles, A Zeleniuch-Jacquotte, C Lawrence, R Montalvan, L Burdett, A Hutchinson, Y Ye, TG Call, TD Shanafelt, AJ Novak, NE Kay, M Liebow, JM Cunningham, C Allmer, H Hjalgrim, HO Adami, M Melbye, B Glimelius, ET Chang, M Glenn, K Curtin, LA Cannon-Albright, WR Diver, BK Link, GJ Weiner, L Conde, PM Bracci, J Riby, DK Arnett, D Zhi, JM Leach, EA Holly, RD Jackson, LF Tinker, Y Benavente, N Sala, D Casabonne, N Becker, P Boffetta, P Brennan, L Foretova, M Maynadie, J McKay, A Staines, KG Chaffee, SJ Achenbach, CM Vachon, LR Goldin, SS Strom, JF Leis, JB Weinberg, NE Caporaso, AD Norman, AJ De Roos, LM Morton, RK Severson, E Riboli, P Vineis, R Kaaks, G Masala, E Weiderpass, MD Chirlaque, RC Vermeulen, RC Travis, MC Southey, RL Milne, D Albanes, J Virtamo, S Weinstein, J Clavel, T Zheng, TR Holford, DJ Villano, A Maria, JJ Spinelli, RD Gascoyne, JM Connors, KA Bertrand, E Giovannucci, P Kraft, A Kricker, J Turner, MG Ennas, GM Ferri, L Miligi, L Liang, B Ma, J Huang, S Crouch, JH Park, N Chatterjee, KE North, JA Snowden, J Wright, JF Fraumeni, K Offit, X Wu, S de Sanjose, JR Cerhan, SJ Chanock, N Rothman, SL Slager

TITLE:

Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia.

JOURNAL:

Nature communications Mar 2016, Vol 7, pp. 10933

ABSTRACT:

Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and 7,667 controls with follow-up replication in 1,958 cases and 5,530 controls. Here we report three new loci at 3p24.1 (rs9880772, EOMES, P=2.55 × 10(-11)), 6p25.2 (rs73718779, SERPINB6, P=1.97 × 10(-8)) and 3q28 (rs9815073, LPP, P=3.62 × 10(-8)), as well as a new independent SNP at the known 2q13 locus (rs9308731, BCL2L11, P=1.00 × 10(-11)) in the combined analysis. We find suggestive evidence (P<5 × 10(-7)) for two additional new loci at 4q24 (rs10028805, BANK1, P=7.19 × 10(-8)) and 3p22.2 (rs1274963, CSRNP1, P=2.12 × 10(-7)). Pathway analyses of new and known CLL loci consistently show a strong role for apoptosis, providing further evidence for the importance of this biological pathway in CLL susceptibility. PUBMED: 26956414
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