DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Ulcerative colitis. The EFO term ulcerative colitis was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: ulcerative colitis

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

CA Anderson, G Boucher, CW Lees, A Franke, M D'Amato, KD Taylor, JC Lee, P Goyette, M Imielinski, A Latiano, C Lagacé, R Scott, L Amininejad, S Bumpstead, L Baidoo, RN Baldassano, M Barclay, TM Bayless, S Brand, C Büning, JF Colombel, LA Denson, M De Vos, M Dubinsky, C Edwards, D Ellinghaus, RS Fehrmann, JA Floyd, T Florin, D Franchimont, L Franke, M Georges, J Glas, NL Glazer, SL Guthery, T Haritunians, NK Hayward, JP Hugot, G Jobin, D Laukens, I Lawrance, M Lémann, A Levine, C Libioulle, E Louis, DP McGovern, M Milla, GW Montgomery, KI Morley, C Mowat, A Ng, W Newman, RA Ophoff, L Papi, O Palmieri, L Peyrin-Biroulet, J Panés, A Phillips, NJ Prescott, DD Proctor, R Roberts, R Russell, P Rutgeerts, J Sanderson, M Sans, P Schumm, F Seibold, Y Sharma, LA Simms, M Seielstad, AH Steinhart, SR Targan, LH van den Berg, M Vatn, H Verspaget, T Walters, C Wijmenga, DC Wilson, HJ Westra, RJ Xavier, ZZ Zhao, CY Ponsioen, V Andersen, L Torkvist, M Gazouli, NP Anagnou, TH Karlsen, L Kupcinskas, J Sventoraityte, JC Mansfield, S Kugathasan, MS Silverberg, J Halfvarson, JI Rotter, CG Mathew, AM Griffiths, R Gearry, T Ahmad, SR Brant, M Chamaillard, J Satsangi, JH Cho, S Schreiber, MJ Daly, JC Barrett, M Parkes, V Annese, H Hakonarson, G Radford-Smith, RH Duerr, S Vermeire, RK Weersma, JD Rioux

TITLE:

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.

JOURNAL:

Nature genetics Mar 2011, Vol 43, pp. 246-52

ABSTRACT:

Genome-wide association studies and candidate gene studies in ulcerative colitis have identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis genome-wide association study datasets, comprising 6,687 cases and 19,718 controls, and followed up the top association signals in 9,628 cases and 12,917 controls. We identified 29 additional risk loci (P < 5 × 10(-8)), increasing the number of ulcerative colitis-associated loci to 47. After annotating associated regions using GRAIL, expression quantitative trait loci data and correlations with non-synonymous SNPs, we identified many candidate genes that provide potentially important insights into disease pathogenesis, including IL1R2, IL8RA-IL8RB, IL7R, IL12B, DAP, PRDM1, JAK2, IRF5, GNA12 and LSP1. The total number of confirmed inflammatory bowel disease risk loci is now 99, including a minimum of 28 shared association signals between Crohn's disease and ulcerative colitis. PUBMED: 21297633
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