DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Airflow obstruction. The EFO term pulmonary function measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: pulmonary function measurement

SCORE TYPE:

P-Value

THRESHOLD:

<= 0.05

GENES IN THRESHOLD:

37

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-10-22

SPECIES:

AUTHORS:

JB Wilk, NR Shrine, LR Loehr, JH Zhao, A Manichaikul, LM Lopez, AV Smith, SR Heckbert, J Smolonska, W Tang, DW Loth, I Curjuric, J Hui, MH Cho, JC Latourelle, AP Henry, M Aldrich, P Bakke, TH Beaty, AR Bentley, IB Borecki, GG Brusselle, KM Burkart, TH Chen, D Couper, JD Crapo, G Davies, J Dupuis, N Franceschini, A Gulsvik, DB Hancock, TB Harris, A Hofman, M Imboden, AL James, KT Khaw, L Lahousse, LJ Launer, A Litonjua, Y Liu, KK Lohman, DA Lomas, T Lumley, KD Marciante, WL McArdle, B Meibohm, AC Morrison, AW Musk, RH Myers, KE North, DS Postma, BM Psaty, SS Rich, F Rivadeneira, T Rochat, JI Rotter, M Soler Artigas, JM Starr, AG Uitterlinden, NJ Wareham, C Wijmenga, P Zanen, MA Province, EK Silverman, IJ Deary, LJ Palmer, PA Cassano, V Gudnason, RG Barr, RJ Loos, DP Strachan, SJ London, HM Boezen, N Probst-Hensch, SA Gharib, IP Hall, GT O'Connor, MD Tobin, BH Stricker

TITLE:

Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.

JOURNAL:

American journal of respiratory and critical care medicine Oct 2012, Vol 186, pp. 622-32

ABSTRACT:

Genome-wide association studies (GWAS) have identified loci influencing lung function, but fewer genes influencing chronic obstructive pulmonary disease (COPD) are known. PUBMED: 22837378
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