DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Response to inhaled corticosteroid treatment in asthma (change in FEV1). The EFO term FEV change measurement, response to corticosteroid, asthma was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: FEV change measurement, response to corticosteroid, asthma

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

TJ Park, JS Park, HS Cheong, BL Park, LH Kim, JS Heo, YK Kim, KU Kim, ST Uh, HS Lee, JO Na, KH Seo, JS Choi, YH Kim, MS Kim, CS Park, HD Shin

TITLE:

Genome-wide association study identifies ALLC polymorphisms correlated with FEV₁ change by corticosteroid.

JOURNAL:

Clinica chimica acta; international journal of clinical chemistry Sep 2014, Vol 436, pp. 20-6

ABSTRACT:

Asthma can be suppressed by inhaled corticosteroids (ICS). However, response to ICS shows marked inter-individual variability. This study is aimed to identify the genetic variants associated with the change in the percentage of forced expiratory volume in 1second (%ΔFEV1) following ICS treatment. PUBMED: 24792382
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