DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Glioma (high-grade). The EFO term central nervous system cancer was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: central nervous system cancer

SCORE TYPE:

P-Value

THRESHOLD:

<= 0.05

GENES IN THRESHOLD:

5

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-10-22

SPECIES:

AUTHORS:

KM Walsh, V Codd, IV Smirnov, T Rice, PA Decker, HM Hansen, T Kollmeyer, ML Kosel, AM Molinaro, LS McCoy, PM Bracci, BS Cabriga, M Pekmezci, S Zheng, JL Wiemels, AR Pico, T Tihan, MS Berger, SM Chang, MD Prados, DH Lachance, BP O'Neill, H Sicotte, JE Eckel-Passow, P van der Harst, JK Wiencke, NJ Samani, RB Jenkins, MR Wrensch

TITLE:

Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk.

JOURNAL:

Nature genetics Jul 2014, Vol 46, pp. 731-5

ABSTRACT:

Glioma, the most common central nervous system cancer in adults, has poor prognosis. Here we identify a new SNP associated with glioma risk, rs1920116 (near TERC), that reached genome-wide significance (Pcombined = 8.3 × 10(-9)) in a meta-analysis of genome-wide association studies (GWAS) of high-grade glioma and replication data (1,644 cases and 7,736 controls). This region has previously been associated with mean leukocyte telomere length (LTL). We therefore examined the relationship between LTL and both this new risk locus and other previously established risk loci for glioma using data from a recent GWAS of LTL (n = 37,684 individuals). Alleles associated with glioma risk near TERC and TERT were strongly associated with longer LTL (P = 5.5 × 10(-20) and 4.4 × 10(-19), respectively). In contrast, risk-associated alleles near RTEL1 were inconsistently associated with LTL, suggesting the presence of distinct causal alleles. No other risk loci for glioma were associated with LTL. The identification of risk alleles for glioma near TERC and TERT that also associate with telomere length implicates telomerase in gliomagenesis. PUBMED: 24908248
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