DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Iron status biomarkers. The EFO term iron biomarker measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: iron biomarker measurement

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

B Benyamin, MA Ferreira, G Willemsen, S Gordon, RP Middelberg, BP McEvoy, JJ Hottenga, AK Henders, MJ Campbell, L Wallace, IH Frazer, AC Heath, EJ de Geus, DR Nyholt, PM Visscher, BW Penninx, DI Boomsma, NG Martin, GW Montgomery, JB Whitfield

TITLE:

Common variants in TMPRSS6 are associated with iron status and erythrocyte volume.

JOURNAL:

Nature genetics Nov 2009, Vol 41, pp. 1173-5

ABSTRACT:

We report a genome-wide association study to iron status. We identify an association of SNPs in TPMRSS6 to serum iron (rs855791, combined P = 1.5 x 10(-20)), transferrin saturation (combined P = 2.2 x 10(-23)) and erythrocyte mean cell volume (MCV, combined P = 1.1 x 10(-10)). We also find suggestive evidence of association with blood hemoglobin levels (combined P = 5.3 x 10(-7)). These findings demonstrate the involvement of TMPRSS6 in control of iron homeostasis and in normal erythropoiesis. PUBMED: 19820699
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