DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Interleukin-18 levels. The EFO term interleukin 18 measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: interleukin 18 measurement

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

M He, MC Cornelis, P Kraft, RM van Dam, Q Sun, CC Laurie, DB Mirel, DI Chasman, PM Ridker, DJ Hunter, FB Hu, L Qi

TITLE:

Genome-wide association study identifies variants at the IL18-BCO2 locus associated with interleukin-18 levels.

JOURNAL:

Arteriosclerosis, thrombosis, and vascular biology Apr 2010, Vol 30, pp. 885-90

ABSTRACT:

Interleukin-18 (IL-18) is a proinflammatory cytokine involved in the processes of innate and acquired immunities and associated with cardiovascular disease and type 2 diabetes. We sought to identify the common genetic variants associated with IL-18 levels. PUBMED: 20150558
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