DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Type 2 diabetes. The EFO term type II diabetes mellitus was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: type II diabetes mellitus

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2020-05-06

SPECIES:

AUTHORS:

M Imamura, A Takahashi, T Yamauchi, K Hara, K Yasuda, N Grarup, W Zhao, X Wang, A Huerta-Chagoya, C Hu, S Moon, J Long, SH Kwak, A Rasheed, R Saxena, RC Ma, Y Okada, M Iwata, J Hosoe, N Shojima, M Iwasaki, H Fujita, K Suzuki, J Danesh, T Jørgensen, ME Jørgensen, DR Witte, I Brandslund, C Christensen, T Hansen, JM Mercader, J Flannick, H Moreno-Macías, NP Burtt, R Zhang, YJ Kim, W Zheng, JR Singh, CH Tam, H Hirose, H Maegawa, C Ito, K Kaku, H Watada, Y Tanaka, K Tobe, R Kawamori, M Kubo, YS Cho, JC Chan, D Sanghera, P Frossard, KS Park, XO Shu, BJ Kim, JC Florez, T Tusié-Luna, W Jia, ES Tai, O Pedersen, D Saleheen, S Maeda, T Kadowaki

TITLE:

Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes.

JOURNAL:

Nature communications Jan 2016, Vol 7, pp. 10531

ABSTRACT:

Genome-wide association studies (GWAS) have identified more than 80 susceptibility loci for type 2 diabetes (T2D), but most of its heritability still remains to be elucidated. In this study, we conducted a meta-analysis of GWAS for T2D in the Japanese population. Combined data from discovery and subsequent validation analyses (23,399 T2D cases and 31,722 controls) identify 7 new loci with genome-wide significance (P<5 × 10(-8)), rs1116357 near CCDC85A, rs147538848 in FAM60A, rs1575972 near DMRTA1, rs9309245 near ASB3, rs67156297 near ATP8B2, rs7107784 near MIR4686 and rs67839313 near INAFM2. Of these, the association of 4 loci with T2D is replicated in multi-ethnic populations other than Japanese (up to 65,936 T2Ds and 158,030 controls, P<0.007). These results indicate that expansion of single ethnic GWAS is still useful to identify novel susceptibility loci to complex traits not only for ethnicity-specific loci but also for common loci across different ethnicities. PUBMED: 26818947
Find other GeneSets from this publication