DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Infantile hypertrophic pyloric stenosis. The EFO term infantile hypertrophic pyloric stenosis was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: infantile hypertrophic pyloric stenosis

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

B Feenstra, F Geller, L Carstensen, PA Romitti, IB Körberg, B Bedell, C Krogh, R Fan, A Svenningsson, M Caggana, A Nordenskjöld, JL Mills, JC Murray, M Melbye

TITLE:

Plasma lipids, genetic variants near APOA1, and the risk of infantile hypertrophic pyloric stenosis.

JOURNAL:

JAMA Aug 2013, Vol 310, pp. 714-21

ABSTRACT:

Infantile hypertrophic pyloric stenosis (IHPS) is a serious condition in which hypertrophy of the pyloric sphincter muscle layer leads to gastric outlet obstruction. Infantile hypertrophic pyloric stenosis shows strong familial aggregation and heritability, but knowledge about specific genetic risk variants is limited. PUBMED: 23989729
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