DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Nephropathy. The EFO term kidney disease was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: kidney disease

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

AG Gharavi, K Kiryluk, M Choi, Y Li, P Hou, J Xie, S Sanna-Cherchi, CJ Men, BA Julian, RJ Wyatt, J Novak, JC He, H Wang, J Lv, L Zhu, W Wang, Z Wang, K Yasuno, M Gunel, S Mane, S Umlauf, I Tikhonova, I Beerman, S Savoldi, R Magistroni, GM Ghiggeri, M Bodria, F Lugani, P Ravani, C Ponticelli, L Allegri, G Boscutti, G Frasca, A Amore, L Peruzzi, R Coppo, C Izzi, BF Viola, E Prati, M Salvadori, R Mignani, L Gesualdo, F Bertinetto, P Mesiano, A Amoroso, F Scolari, N Chen, H Zhang, RP Lifton

TITLE:

Genome-wide association study identifies susceptibility loci for IgA nephropathy.

JOURNAL:

Nature genetics Mar 2011, Vol 43, pp. 321-7

ABSTRACT:

We carried out a genome-wide association study of IgA nephropathy, a major cause of kidney failure worldwide. We studied 1,194 cases and 902 controls of Chinese Han ancestry, with targeted follow up in Chinese and European cohorts comprising 1,950 cases and 1,920 controls. We identified three independent loci in the major histocompatibility complex, as well as a common deletion of CFHR1 and CFHR3 at chromosome 1q32 and a locus at chromosome 22q12 that each surpassed genome-wide significance (P values for association between 1.59 × 10⁻²⁶ and 4.84 × 10⁻⁹ and minor allele odds ratios of 0.63-0.80). These five loci explain 4-7% of the disease variance and up to a tenfold variation in interindividual risk. Many of the alleles that protect against IgA nephropathy impart increased risk for other autoimmune or infectious diseases, and IgA nephropathy risk allele frequencies closely parallel the variation in disease prevalence among Asian, European and African populations, suggesting complex selective pressures. PUBMED: 21399633
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