DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Atrial fibrillation. The EFO term atrial fibrillation was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: atrial fibrillation

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

PT Ellinor, KL Lunetta, NL Glazer, A Pfeufer, A Alonso, MK Chung, MF Sinner, PI de Bakker, M Mueller, SA Lubitz, E Fox, D Darbar, NL Smith, JD Smith, RB Schnabel, EZ Soliman, KM Rice, DR Van Wagoner, BM Beckmann, C van Noord, K Wang, GB Ehret, JI Rotter, SL Hazen, G Steinbeck, AV Smith, LJ Launer, TB Harris, S Makino, M Nelis, DJ Milan, S Perz, T Esko, A Köttgen, S Moebus, C Newton-Cheh, M Li, S Möhlenkamp, TJ Wang, WH Kao, RS Vasan, MM Nöthen, CA MacRae, BH Stricker, A Hofman, AG Uitterlinden, D Levy, E Boerwinkle, A Metspalu, EJ Topol, A Chakravarti, V Gudnason, BM Psaty, DM Roden, T Meitinger, HE Wichmann, JC Witteman, J Barnard, DE Arking, EJ Benjamin, SR Heckbert, S Kääb

TITLE:

Common variants in KCNN3 are associated with lone atrial fibrillation.

JOURNAL:

Nature genetics Mar 2010, Vol 42, pp. 240-4

ABSTRACT:

Atrial fibrillation (AF) is the most common sustained arrhythmia. Previous studies have identified several genetic loci associated with typical AF. We sought to identify common genetic variants underlying lone AF. This condition affects a subset of individuals without overt heart disease and with an increased heritability of AF. We report a meta-analysis of genome-wide association studies conducted using 1,335 individuals with lone AF (cases) and 12,844 unaffected individuals (referents). Cases were obtained from the German AF Network, Heart and Vascular Health Study, the Atherosclerosis Risk in Communities Study, the Cleveland Clinic and Massachusetts General Hospital. We identified an association on chromosome 1q21 to lone AF (rs13376333, adjusted odds ratio = 1.56; P = 6.3 x 10(-12)), and we replicated this association in two independent cohorts with lone AF (overall combined odds ratio = 1.52, 95% CI 1.40-1.64; P = 1.83 x 10(-21)). rs13376333 is intronic to KCNN3, which encodes a potassium channel protein involved in atrial repolarization. PUBMED: 20173747
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