DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Chronic obstructive pulmonary disease. The EFO term chronic obstructive pulmonary disease was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: chronic obstructive pulmonary disease

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

MH Cho, N Boutaoui, BJ Klanderman, JS Sylvia, JP Ziniti, CP Hersh, DL DeMeo, GM Hunninghake, AA Litonjua, D Sparrow, C Lange, S Won, JR Murphy, TH Beaty, EA Regan, BJ Make, JE Hokanson, JD Crapo, X Kong, WH Anderson, R Tal-Singer, DA Lomas, P Bakke, A Gulsvik, SG Pillai, EK Silverman

TITLE:

Variants in FAM13A are associated with chronic obstructive pulmonary disease.

JOURNAL:

Nature genetics Mar 2010, Vol 42, pp. 200-2

ABSTRACT:

We performed a genome-wide association study for chronic obstructive pulmonary disease (COPD) in three population cohorts, including 2,940 cases and 1,380 controls who were current or former smokers with normal lung function. We identified a new susceptibility locus at 4q22.1 in FAM13A and replicated this association in one case-control group (n = 1,006) and two family-based cohorts (n = 3,808) (rs7671167, combined P = 1.2 x 10(-11), combined odds ratio in case-control studies 0.76, 95% confidence interval 0.69-0.83). PUBMED: 20173748
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