DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Polycystic ovary syndrome. The EFO term polycystic ovary syndrome was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: polycystic ovary syndrome

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Y Shi, H Zhao, Y Shi, Y Cao, D Yang, Z Li, B Zhang, X Liang, T Li, J Chen, J Shen, J Zhao, L You, X Gao, D Zhu, X Zhao, Y Yan, Y Qin, W Li, J Yan, Q Wang, J Zhao, L Geng, J Ma, Y Zhao, G He, A Zhang, S Zou, A Yang, J Liu, W Li, B Li, C Wan, Y Qin, J Shi, J Yang, H Jiang, JE Xu, X Qi, Y Sun, Y Zhang, C Hao, X Ju, D Zhao, CE Ren, X Li, W Zhang, Y Zhang, J Zhang, D Wu, C Zhang, L He, ZJ Chen

TITLE:

Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome.

JOURNAL:

Nature genetics Sep 2012, Vol 44, pp. 1020-5

ABSTRACT:

Following a previous genome-wide association study (GWAS 1) including 744 cases and 895 controls, we analyzed genome-wide association data from a new cohort of Han Chinese (GWAS 2) with 1,510 polycystic ovary syndrome (PCOS) cases and 2,016 controls. We followed up significantly associated signals identified in the combined results of GWAS 1 and 2 in a total of 8,226 cases and 7,578 controls. In addition to confirming the three loci we previously reported, we identify eight new PCOS association signals at P < 5 × 10(-8): 9q22.32, 11q22.1, 12q13.2, 12q14.3, 16q12.1, 19p13.3, 20q13.2 and a second independent signal at 2p16.3 (the FSHR gene). These PCOS association signals show evidence of enrichment for candidate genes related to insulin signaling, sexual hormone function and type 2 diabetes (T2D). Other candidate genes were related to calcium signaling and endocytosis. Our findings provide new insight and direction for discovering the biological mechanisms of PCOS. PUBMED: 22885925
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